《生命科学》 2025, 37(2): 147-157
基于铜死亡的癌症纳米疗法研究进展
摘 要：
铜死亡是一种非凋亡的程序性细胞死亡方式。随着生物医学纳米技术的发展，铜死亡作为肿瘤的新兴治疗方法，其通过诱导线粒体蛋白寡聚和引发蛋白毒性应激，显著增强肿瘤细胞的杀伤效果。基于铜死亡的纳米药物不仅能有效、快速地将更多的铜转运到肿瘤细胞中，还有助于实现协同治疗的效果。相比传统的癌症治疗方式，铜死亡展示出了一定的优势，例如其整体毒性较低等。因此，本文概述了铜死亡与生物医学纳米技术的最新进展，简要介绍了铜死亡和纳米治疗的研究背景，并阐述了铜死亡驱动下的纳米疗法在癌症治疗中的可行性；回顾了铜离子稳态及铜死亡机制的相关研究，并讨论了以铜死亡为基础的联合疗法，包括将铜死亡与光疗、声疗、化疗和免疫调节相结合的新兴纳米疗法；最后，展望了由铜死亡驱动的生物医学纳米治疗技术在临床肿瘤治疗中的应用前景与面临的挑战。
通讯作者：刘春雷 , Email:liuchunlei1969@126.com
Abstract:
Cuproptosis is a non-apoptotic programmed cell death. With the development of biomedical
nanotechnology, cuproptosis has become an emerging treatment method for tumors, which significantly enhances the killing effect of tumor cells by inducing mitochondrial protein oligomerization and triggering proteotoxic stress. Nano-drugs based on cuproptosis can not only effectively and rapidly transport more copper into tumor cells, but also help to achieve the effect of synergistic therapy. Compared with traditional cancer treatment methods, cuproptosis offers several advantages, such as lower overall toxicity. Therefore, we provide an overview of recent advances in cuproptosis and biomedical nanotechnology. In this paper, we first briefly introduce the research background of cuproptosis and nanotherapy, and expound the feasibility of cuproptosis-driven nanotherapy in cancer treatment. Then, we review the research on copper homeostasis and the mechanism of cuproptosis, and discuss the combination therapy based on cuproptosis, including the emerging nano therapy combining cuproptosis with phototherapy, sound therapy, chemotherapy and immune regulation. Finally, the application prospects and challenges of biomedical nanotechnology driven by cuproptosis in clinical cancer treatment are prospected.
Communication Author：LIU Chun-Lei , Email:liuchunlei1969@126.com
