《生命科学》 2025, 37(2): 140-146

RCN3生物学功能与在肺损伤修复疾病中的研究进展

石小倩 , 王振艳 , 靳嘉巍^*

首都医科大学附属北京朝阳医院，临床医学研究室，北京 100

摘　要：

Reticulocalbin 3 (RCN3) 广泛表达于人体所有组织中，在生理代谢、肺发育、急慢性呼吸疾病、心脑血管疾病及多种肿瘤中均发挥调控作用，尤其是在肺损伤修复相关疾病中发挥重要调控作用。近年来，RCN3 因其生物学功能多样性受到人们的广泛关注。本文对RCN3 的生物学功能以及在肺纤维化、急性呼吸窘迫综合征、慢性阻塞性肺疾病中的研究进展和分子机制进行综述，为今后RCN3 辅助临床诊断及作为
临床治疗新靶点提供参考依据。

通讯作者：靳嘉巍 , Email:jiaweijin@ccmu.edu.cn

Biological function of RCN3 and advances in the repair of lung injury

SHI Xiao-Qian , WANG Zhen-Yan , JIN Jia-Wei^*

Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100043, China

Abstract:

Reticulocalbin 3 (RCN3) is widely expressed in all tissues of the human body, which plays a regulatory role in lung development, acute and chronic respiratory diseases, cardiovascular and cerebrovascular diseases, physiological metabolic processes and a variety of tumors, especially in lung injury repair related diseases. In recent years, RCN3 has attracted much attention due to its biological function diversity. In this paper, the biological function of RCN3 and its research progress and molecular mechanism in pulmonary fibrosis, acute respiratory distress syndrome, and chronic obstructive pulmonary disease were reviewed, so as to provide reference for RCN3 as a target for auxiliary clinical diagnosis and clinical treatment in the future.

Communication Author：JIN Jia-Wei , Email:jiaweijin@ccmu.edu.cn