《生命科学》 2025, 37(1): 37-46
代谢整合生物学的研究发展态势
摘 要：
代谢整合生物学作为整合生物学的重要分支，旨在从整体、系统及跨层级的视角，深入探究生物体内物质和能量代谢的客观规律及精细调控机制。本文总结了近年来，特别是2024 年该领域的研究发展态势，从理论建构、研究项目、研究进展、研究展望四个维度进行了系统剖析梳理。在理论建构方面，生物钟与能量代谢关系的研究成果丰硕，揭示了关键调控因子协同、生物钟信号传递、代谢物浓度变化等多种作用模式，而社会学思路的引入为解析代谢稳态调控机理提供了新的视角；在项目布局方面，多个研究项目不同程度地体现了整合生物学的特点，为相关领域提供了支撑；在研究进展方面，新陈代谢与神经调控之间存在复杂的双向互动网络，器官间通过代谢轴紧密相连共同维持整体代谢稳态，而代谢与衰老之间的相互作用复杂，涉及代谢重编程、生理系统失调、能量代谢变化等多个层面。展望未来，随着人工智能、大数据等技术的发展与广泛应用，代谢整合生物学研究将围绕理论深化、技术创新及应用拓展等全方位展开，有望为生命科学与健康产业带来全新的突破与变革。
通讯作者：陈大明 , Email:chendaming@sinh.ac.cn 应 浩 , Email:yinghao@sinh.ac.cn
Abstract:
Metabolic integrative biology as an important branch of integrative biology, aims to investigate the underlying principles and fine regulatory mechanisms of material and energy metabolism in organisms from a macro, holistic, systematic, and cross-level perspective. This paper summarizes the development trend of this research field, particularly since 2024, and provides a systematic analysis across four dimensions: theoretical construction, research projects, research progress, and research prospects. In terms of theoretical construction, fruitful achievements in understanding the relationship between the circadian clock and energy metabolism have revealed various modes of action, including the coordination of key regulatory factors, the transduction of circadian signals, and changes in metabolite concentrations. The introduction of sociological perspectives has provided new insights into elucidating the mechanisms of metabolic homeostasis regulation. Regarding research projects, several initiatives have embodied the characteristics of Integrative Biology to varying degrees, providing strong support for related fields. In terms of research progress, there exists a complex bidirectional interaction network between metabolism and neural regulation. Organs are tightly linked through metabolic axes to coordinate overall metabolic homeostasis. The interaction between metabolism and aging is complex, involving metabolic reprogramming, physiological system dysregulation, and changes in energy. Looking ahead, research in Metabolic Integrative Biology will comprehensively focus on theoretical deepening, technological innovation, and application expansion, promising to bring new breakthroughs and transformations to life sciences and the health industry.
Communication Author：CHEN Da-Ming , Email:chendaming@sinh.ac.cn YING Hao , Email:yinghao@sinh.ac.cn
