《生命科学》 2024, 36(12): 1562-1571

环形RNA数据库汇总及其应用

许钊源¹ , 王豫琪¹ , 何璐云^2,*

¹郑州大学第一临床医学院，郑州 450001 ²郑州大学基础医学院病理生理学系，郑州 450001

摘　要：

环形RNA (circular RNA, circRNA) 是通过反向剪接形成的闭合非编码RNA 分子。它可以通过多种方式参与细胞生命活动，同时也是肿瘤等多种疾病的生物标志物和潜在治疗靶点。随着高通量测序技术的发展和circRNA 研究的不断深入，circRNA 信息和功能注释不断增加。许多聚焦不同方向的circRNA 数据库被建立，为circRNA 研究者了解、分析、注释及研究circRNA 提供了很大便利。本文收集了28 个circRNA 数据库并对其进行分类汇总，希望为研究者选择circRNA 数据库提供一些参考和帮助。

通讯作者：何璐云 , Email:hly2020@zzu.edu.cn

circRNA databases and the application

XU Zhao-Yuan¹ , WANG Yu-Qi¹ , HE Lu-Yun^2,*

¹First Clinical Medical College, Zhengzhou University, Zhengzhou 450001, China ²Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China

Abstract:

circular RNAs (circRNAs) are closed non-coding RNA molecules formed by back-splicing. circRNAs  can involve in cell life by a variety of ways, and they are also  biomarkers and potential therapeutic targets for a variety of diseases including cancers. With the  development of high-throughput sequencing technology and the deepening research, the information and functional annotations of circRNAs become more and more. A  number of circRNA databases focusing on different contents have been established, providing great convenience for circRNA researchers to understand, analyze, annotate and study circRNAs. In this paper, 28 established circRNA databases are collected and classified, in order to provide references when selecting circRNA databases.

Communication Author：HE Lu-Yun , Email:hly2020@zzu.edu.cn