《生命科学》 2004, 16(1):

血管内皮生长因子家族及其受体与肿瘤血管生成研究进展

陈　珊¹，金　伟¹，闵　平¹，陆　核²

1 中国科学院上海药物研究所，上海 201203；2 上海市瑞金医院中法实验室，上海 200025

摘　要：摘　要：血管内皮生长因子(vascular endothelial growth factor, VEGF)，又名血管通透性因子(vascular permeability factor, VPF)是重要的血管生成正性调节因子,是目前抗癌治疗的研究靶点之一。现已发现的VEGF家族成员包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和胎盘生长因子(placenta growth factor, PLGF)。VEGF的受体有VEGFR-1(flt-1)、 VEGFR-2(flk-1/KDR)、 VEGFR-3(flt-4)、 neuropilin(NPR1/NPR2)。该家族的成员可以选择性地增强血管和/或淋巴管内皮细胞的有丝分裂，刺激内皮细胞增殖并促进血管生成，提高血管特别是微小血管的通透性，使血浆大分子外渗沉积在血管外的基质中，促进新生毛细血管网的建立，为肿瘤细胞的生长提供营养等。作者对VEGF家族成员及其受体的理化特征、VEGF与肿瘤的关系、VEGF抑制剂的研制作一综述。
关键词：血管内皮生长因子；血管内皮生长因子受体；肿瘤血管生成

Review of relationship between vascular endothelial growth factor family & receptors and tumor angiogenesis

CHEN Shan¹, JIN Wei¹, MIN Ping¹, LU He²

1 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2 Le pole francochinois du science du vivant et genomique, Ruijin Hospital, Shanghai 200025, China

Abstract:
Abstract: Vascular endothelial growth factor (VEGF) also named vascular permeability factor (VPF), is an important positive regulator for angiogenesis. This is one target of the anticancer research. Discovered members of VEGF family include: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E and placenta growth factor (PLGF). Receptors of  VEGF are VEGFR-1(flt-1), VEGFR-2(flk-1/KDR), VEGFR-3(flt-4) and neuropilin(NPR1/NPR2). Members of this family can selectively promote mitosis of vascular endotheial cells or lymphatic endothelial cells, stimulate endothelial cells to proliferate and induce angiogenesis. They also enhance the permeability of microvessels, help to establish capillary vessels net. This article mainly reviewed the structures, functional characteristics, relationship between VEGF and its inhibitors and tumor angiogenesis.
Key words: vascular endothelial growth factor; vascular endothelial growth factors receptors; angiogenesis