《生命科学》 2024, 36(12): 1535-1542

lncRNA对缺血性脑卒中后血管新生作用的研究进展

郑　铂^1,2 , 陈　越^1,2,3 , 王锦坤^1,2 , 李米亚^1,2 , 李晓娟^1,2 , 何　治^1,2,3,*

¹三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002 ²三峡大学基础医学院，宜昌 443002 ³嘉兴大学医学院，嘉兴 314000

摘　要：

缺血性脑卒中是一种高致残率和高致死率的疾病，对人类健康构成了严重威胁。近年来，长链非编码核糖核酸(long non-coding RNA, lncRNA) 在缺血性脑卒中中的作用受到了越来越多的关注。它不仅通过调控基因表达和细胞功能影响缺血性脑卒中的发生和发展，还在缺血性脑卒中后的脑血管新生过程中发挥着至关重要的作用，而促进脑血管新生有助于恢复缺血部位的血液供应、改善患者的预后。因此，深入探索缺血性脑卒中后lncRNA 在脑血管新生中的具体作用机制，具有重要的临床和研究意义。本文详细综述了lncRNA 在缺血性脑卒中后脑血管新生中的作用及其潜在的分子机制，旨在为未来的相关研究方向提供理论依据，并为临床诊疗提供新的思路和策略。

通讯作者：何　治 , Email:462409381@qq.com

Research progress of lncRNA on angiogenesis after ischemic stroke

ZHENG Bo^1,2 , CHEN Yue^1,2,3 , WANG Jin-Kun^1,2 , LI Mi-Ya^1,2 , LI Xiao-Juan^1,2 , HE Zhi^1,2,3,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China ²College of Basic Medical Science, China Three Gorges University, Yichang 443002, China ³Jiaxing University School of Medicine, Jiaxing 314000, China

Abstract:

Ischemic stroke is a disease with high rates of disability and mortality, posing a severe threat to human health. In recent years, increasing attention has been focused on the role of long non-coding RNAs (lncRNAs) in ischemic stroke. LncRNAs not only influence the occurrence and progression of ischemic stroke by regulating gene expression and cellular functions, but also play a crucial role in cerebrovascular angiogenesis. Promoting cerebrovascular angiogenesis contributes to the  restoration of blood supply to ischemic areas and  improves patient prognosis. Therefore, in-depth exploration of the specific mechanisms of lncRNAs in cerebrovascular angiogenesis following ischemic stroke holds significant clinical and research implications. This review provides a comprehensive overview of the roles and potential molecular mechanisms of lncRNAs in cerebrovascular angiogenesis after ischemic stroke. The aim is to provide a theoretical basis for future research directions and offer new insights and strategies for clinical diagnosis and treatment.

Communication Author：HE Zhi , Email:462409381@qq.com