《生命科学》 2024, 36(12): 1525-1534

HIF-1α在新生儿缺血缺氧性脑损伤中的作用

兰　平^1,2 , 尚文豆^1,2 , 何　治^1,2,3,* , 陈　越^1,2,3,*

¹三峡大学国家中药管理局中药药理科研三级实验室，宜昌 443002 ²三峡大学基础医学院，宜昌 443002 ³嘉兴大学医学院，嘉兴 314000

摘　要：

新生儿缺血缺氧性脑损伤(neonatal hypoxic ischemic brain damage, HIBD) 是指围产期因多种不利因素导致新生儿大脑部分或完全缺血缺氧而引起的脑损伤疾病，其致死率和致残率高，发病机制复杂。缺氧诱导因子-1α (hypoxia-inducible factor-1α, HIF-1α) 是调节细胞适应缺氧环境的关键转录因子。在HIBD 中，HIF-1α 的表达对神经元既有保护作用也有毒性作用，主要与新生儿大脑缺血缺氧的时间和程度有关。本文就HIF-1α 及其所调控的下游基因在HIBD 中的具体作用机制进行综述。

通讯作者：何　治 , Email:329856208@qq.com 陈　越 , Email:yueyue.cc11@foxmail.com

The role of HIF-1α in neonatal hypoxic ischemic brain damage

LAN Ping^1,2 , SHANG Wen-Dou^1,2 , HE Zhi^1,2,3,* , CHEN Yue^1,2,3,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China ²Basic Medical College, China Three Gorges University, Yichang 443002, China ³Jiaxing University Medical College, Jiaxing 314000, China

Abstract:

Neonatal hypoxic ischemic brain damage (HIBD) is the major cause of mortality and morbidity to the newborn in the perinatal period, which results from partially or  completely ischemia and hypoxia to the brain of neonates and leads to brain injury. HIBD is highly lethal and  disabling, and its pathogenesis is complicated and not completely clear. Hypoxia-inducible factor-1α (HIF-1α) is a key transcription factor regulating cellular adaptation to hypoxic environments. In HIBD, HIF-1α has both  neuroprotective and neurotoxic effects, mainly related to the duration and degree of neonatal cerebral ischemia and hypoxia. The research evidence of HIF-1α in HIBD and downstream events, as well as the specific  mechanisms are summarized and discussed in this review.

Communication Author：HE Zhi , Email:329856208@qq.com CHEN Yue , Email:yueyue.cc11@foxmail.com