《生命科学》 2024, 36(12): 1514-1524

IFN-γ在脑缺血中的双重作用

李米亚^1,2 , 陈　越^1,2 , 兰　平^1,2 , 张文欣^1,2 , 何　治^1,2,*

¹三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002 ²三峡大学基础医学院，宜昌 443002

摘　要：

γ 干扰素(interferon gamma, IFN-γ) 是一种具有多种生物学效应的细胞因子，参与体内固有免疫和获得性免疫。近年研究发现IFN-γ 与脑缺血的病理生理进程密切相关，IFN-γ 不仅通过介导炎症反应损害血脑屏障促进脑缺血早期T 细胞和NK 细胞浸润等过程对脑缺血性疾病发挥神经损伤作用，也可通过促进神
经再生和在脑缺血恢复期招募CD169 巨噬细胞浸润脑实质等过程发挥神经保护作用。除此之外，IFN-γ 在脑缺血并发症中也发挥不同作用：促进早期卒中后抑郁发病和预防卒中相关性肺炎。该文重点围绕IFN-γ在脑缺血中的双重作用及其临床研究进展进行综述，为防治脑缺血提供研究基础。

通讯作者：何　治 , Email:1603277652@qq.com

The dual role of IFN-γ in cerebral ischemia

LI Mi-Ya^1,2 , CHEN Yue^1,2 , LAN Ping^1,2 , ZHANG Wen-Xin^1,2 , HE Zhi^1,2,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China ²Basic Medical College, China Three Gorges University, Yichang 443002, China

Abstract:

Interferon gamma (IFN-γ) is a cytokine with multiple biological effects, involved in innate and acquired immunity in vivo. Recent studies have found that IFN-γ is closely related to the pathophysiological process of cerebral ischemia. IFN-γ not only mediates inflammatory responses, damages the blood-brain barrier, promotes T cell and NK cell infiltration during the early stage of  cerebral ischemia through various processes, but also play a neuroprotective role by promoting nerve regeneration and recruiting CD169 macrophages to infiltrate the brain
parenchyma during cerebral ischemic recovery. In  addition, IFN-γ also plays a different role in cerebral  ischemia complications: promoting the onset of early post-stroke depression and preventing stroke-associated pneumonia. This article focuses on the dual role of IFN-γ in cerebral ischemia and its clinical research progress to provide research basis for prevention and treatment of cerebral ischemia.

Communication Author：HE Zhi , Email:1603277652@qq.com