《生命科学》 2024, 36(12): 1503-1513

衰老相关分泌表型调控骨组织细胞功能的研究进展

翁凯鸿¹ , 何玉婷¹ , 毛钰蘅² , 翁锡全^2,3,* , 元　宇^2,3,*

¹广州体育学院研究生院，广州 510500 ²广州体育学院运动与健康学院， 广州 510500 ³广州体育学院广东省运动与健康重点实验室，广州 510500

摘　要：

随着人口的老龄化，骨质疏松症已成为全球重要的公共卫生问题之一。骨质疏松与细胞衰老密切相关，细胞老化过程中伴随着衰老相关分泌表型(senescent associated secretory phenotype, SASP) 分泌增多。SASP 包括促炎细胞因子、趋化因子等多种细胞因子，能够加速细胞衰老，影响骨组织细胞功能，打破骨稳态，加速骨衰老进程。近年的研究表明，SASP 有望成为骨质疏松症等骨代谢疾病的治疗靶点。然而，SASP 调控骨组织细胞的确切机制尚未完全阐明。鉴于此，本文对SASP 在骨组织细胞中的调控机制进行综述，可为衰老相关骨代谢疾病的防治提供理论依据。

通讯作者：翁锡全 , Email:wengxq@gzsport.edu.cn 元　宇 , Email:yuany@gzsport.edu.cn

Research progress on senescent associated secretory phenotype in regulating bone tissue cells

WENG Kai-Hong¹ , HE Yu-Ting¹ , MAO Yu-Heng² , WENG Xi-Quan^2,3,* , YUAN Yu^2,3,*

¹Graduate School, Guangzhou Sport University, Guangzhou 510500, China ²School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China ³Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou 510500, China

Abstract:

With the aging population, osteoporosis has become one of the severe global public health issues. Osteoporosis is intimately tied to cellular aging, which in turn is  accompanied by the emergence of the  senescenceassociated secretory phenotype (SASP). SASP, including various cytokines such as pro-inflammatory cytokines and chemokines, can accelerate cellular aging, affect the function of bone tissue cells, disrupt bone homeostasis, and expedite the process of bone aging. Recent studies have indicated that SASP may become a therapeutic target for bone diseases such as osteoporosis. However, the mechanisms by which SASP regulates bone tissue cells remain unclear. In light of this, this review summarizes the regulatory mechanisms of SASP in bone tissue cells, which can provide a theoretical foundation for the prevention and treatment of age-related bone  diseases.

Communication Author：WENG Xi-Quan , Email:wengxq@gzsport.edu.cn YUAN Yu , Email:yuany@gzsport.edu.cn