《生命科学》 2024, 36(12): 1478-1484

CGP和IGF-1在大脑发育和认知障碍中的研究进展

陈巧巧¹ , 杨　杨^2,*

¹武汉科技大学，武汉 430064 ²武汉科技大学附属天佑医院内分泌科，武汉 430064

摘　要：

胰岛素样生长因子-1 (insulin-like growth factor-1, IGF-1) 是一种在改善大脑发育和维持认知功能两方面发挥重要作用的内源性生长因子。IGF-1 随年龄增加的变化是老年性认知障碍发生发展的关键性因素之一。在循环中，IGF-1 与IGF 结合蛋白-3 (IGF-binding protein-3, IGFBP-3) 的可逆结合能调节功能性
IGF-1 含量。而环甘氨酸脯氨酸(cyclic glycine-proline, cGP) 是IGF-1 的代谢产物，能与IGFBP-3 的对应位点结合，即具有与IGF-1 竞争结合IGFBP-3 的能力。因此，cGP 和IGFBP-3 能协同调节IGF-1 的生物活性和生物利用度。临床观察显示，cGP/IGF-1 摩尔比值较高的老年人认知功能较好。本文综述了cGP 和IGF-1在大脑发育以及老年性认知障碍中的研究进展，期望cGP/IGF-1 摩尔比可作为认知功能障碍的新型标志物。

通讯作者：杨　杨 , Email:13554623321@126.com

Research progress of cGP and IGF-1 in brain development and cognitive impairment

CHEN Qiao-Qiao¹ , YANG Yang^2,*

¹Wuhan University of Science and Technology, Wuhan 430064, China ²Department of Endocrinology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430064, China

Abstract:

Insulin-like growth factor-1 (IGF-1) is an endogenous growth factor and plays an important role in brain development and cognitive function. The change of IGF-1 with age is one of the key factors in the development of senile cognitive impairment. The reversible binding of  IGF-1 to IGF-binding protein-3 (IGFBP-3) regulates the amount of bioavailable and functional IGF-1 in circulation. Cyclic glycine-proline (cGP) is a metabolite of IGF-1, which can bind to IGFBP-3. CGP maintains its affinity to IGFBP-3 and competes with IGF-1 for IGFBP-3 binding. As a result, cGP and IGFBP-3 collectively regulate the function of circulating IGF-1. Clinical observations show that elderly individuals with higher cGP/IGF-1 molar ratios have better cognitive function. This article reviews the research progress of cGP and IGF-1 in brain development and senile cognitive impairment, hoping that the molar ratio of cGP/IGF-1 can be used as a new marker of cognitive  impairment.

Communication Author：YANG Yang , Email:13554623321@126.com