《生命科学》 2024, 36(11): 1367-1374

M2型巨噬细胞外泌体microRNAs在肿瘤发生发展中的研究进展

董青林 , 朱怡娴 , 文章雪 , 刘建芳 , 刘　文 , 卢明锋 , 张月杰^*

山东理工大学生命与医药学院，淄博 255000

摘　要：

外泌体是由细胞膜内吞形成并主动分泌至细胞外、直径30~150 nm、在细胞之间执行信息传递和信号转导功能的生物纳米颗粒。外泌体携带的microRNAs (miRNAs) 通过与mRNA 的3'UTR 或者开放阅读框ORF 区域结合，导致靶mRNA 降解或阻碍靶mRNA 翻译，从而介导基因的转录后沉默。单核巨噬细胞是重要的免疫细胞，具有调节免疫防御、肿瘤发生发展和炎症反应等重要作用。本文重点论述M2 型巨噬细胞外泌体miRNAs 在肿瘤细胞增殖凋亡、迁移侵袭、诱导耐药、间质转化、免疫逃逸等方面的影响。

通讯作者：张月杰 , Email:zhangyuejie@sdut.edu.cn

Research progress on M2 macrophage-derived exosomal microRNAs in tumor occurrence and development

DONG Qing-Lin , ZHU Yi-Xian , WEN Zhang-Xue , LIU Jian-Fang , LIU Wen , LU Ming-Feng , ZHANG Yue-Jie^*

School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China

Abstract:

Exosomes are biological nanoparticles with a diameter of 30~150 nm that are formed by endocytosis of the cell membrane and actively secreted into the extracellular space. They perform information and signal transduction functions between cells. The microRNAs (miRNAs) carried by exosomes mediate post-transcriptional silencing of genes by binding to the 3'UTR or open reading frame ORF region of the mRNA, leading to degradation of the target mRNA or blocking the translation of the target mRNA. Mononuclear macrophages are important immune cells and play important roles in regulating immune defense, tumor development and inflammatory responses. This article focuses on the impact of M2 macrophage-derived exosomal miRNAs on tumor proliferation, apoptosis, migration and invasion, induction of drug resistance, mesenchymal transition and immune escape.

Communication Author：ZHANG Yue-Jie , Email:zhangyuejie@sdut.edu.cn