《生命科学》 2004, 16(1):

角质细胞生长因子研究进展

邵寒娟，陈　亮^＊，林　涛

厦门大学生命科学院细胞生物学与肿瘤细胞工程教育部重点实验室，厦门　361005

摘　要：摘　要：角质细胞生长因子(KGF)从属于成纤维细胞生长因子家族。KGF基因表达受多种细胞因子调控。KGF与受体KGFR特异性的结合发挥其多种生物学功能：参与组织、器官的发育；参与皮肤、胃、肠、肾、膀胱、肺等上皮的损伤修复；减少放、化疗所带来的副作用，具有损伤防护功能；KGF与肿瘤密不可分。
关键词：角质细胞生长因子；生物学功能；表达调控

Progress in the studies of keratinocyte growth factor

SHAO Han-Juan, CHEN Liang^＊, LIN Tao

The Education Ministry Key Laboratory of Cell Biology and Tumor Cell Engineering, College of Life Sciences, Xiamen University, Xiamen 361005, China

Abstract:

Abstract:  Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family. A lot of cytokines are responsible for KGF expression. By binding with its receptor KGFR, KGF does its biological functions in repair processes of various tissues and organs, including skin, bowel, bladder, kidney, lung and so on. KGF can stimulate development of some tissues and organs. It also acts as a protective factor on injury induced by radiation and chemotherapy. KGF is concerned with some tumors.
Key words:   keratinocyte growth factor; biological function; expression regulation