《生命科学》 2024, 36(11): 1321-1329

创新生物技术药物研发进展

黄瑶庆 , 李子艳 , 王春丽 , 刘丽丽^*

中国科学院上海药物研究所信息中心，上海 201203

摘　要：

生物医药行业的发展离不开生命科学领域新技术的驱动，技术创新往往会带动整个行业格局发生新的变化。近年来，生物技术的不断革新推动药物研发呈现新趋势。以抗体药物偶联物、双特异性抗体药物、mRNA 药物、CRISPR/Cas9 基因编辑药物为代表的创新生物技术药物取得了突破性的进展。本文结合相关文献和数据库对这些药物的研发情况进行综述。

通讯作者：刘丽丽 , Email:llliu@simm.ac.cn

A brief overview of innovative biotechnological drugs

HUANG Yao-Qing , LI Zi-Yan , WANG Chun-Li , LIU Li-Li^*

Information Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Abstract:

The development of the biopharmaceutical industry is inseparable from the drive of new biotechnology. Technological innovation promotes industrial upgrading. In recent years, innovative drug development has shown new trends with the continuous innovation of biotechnology. This article combines relevant literatures and databases to review the latest progress of antibody drug conjugates, bispecific antibodies, mRNA drugs, and CRISPR/Cas9 gene edited drugs, which have been extensively studied in recent years.

Communication Author：LIU Li-Li , Email:llliu@simm.ac.cn