《生命科学》 2024, 36(7): 962-970

蛋白微阵列芯片技术和产业化发展前景及存在问题

杜卫东^*

安徽医科大学基础医学院病理学教研室，合肥 230032

摘　要：

生物微阵列芯片技术发展日新月异。与基因芯片不同，受蛋白质立体结构、生物学活性、固相载体表面化学修饰物稳定性及检测与分析方法学等方面的影响，蛋白芯片研发及产业化道路曲折艰辛。本文就蛋白微阵列芯片类型、表面化学修饰、芯片研发现状、桎梏及发展趋势作一简要综述。

通讯作者：杜卫东 , Email:weidong.du@ahmu.edu.cn

Prospects and bottlenecks in development and  industrialization of protein biochips

DU Wei-Dong^*

Department of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China

Abstract:

Development of biochip technology remains a great challenge. Unlike gene biochip, the research and  development and industrialization of protein biochip yet runs on a way covered with thorns as a result of influence by intrinsic three-dimensional construction and sustainable biological activity of on-chip proteins, stabilization of surface chemical modification on solid supports and   methodology of detection and analysis. In this review, we have a brief review on types of protein biochips, surface chemical modification, manufacturing  processes, and current R&D status, main shackles and potential trends in biochip research and development.

Communication Author：DU Wei-Dong , Email:weidong.du@ahmu.edu.cn