《生命科学》 2024, 36(7): 898-905
TBC蛋白在人类疾病中的研究进展
摘 要:
TBC 蛋白,作为含Tre2-Bub2-Cdc16 (TBC) 结构域的GTP 酶激活因子,对Rab 蛋白的负调控发挥着关键作用。这一结构域集成了Tre2 原癌基因、Bub2 酵母细胞周期调节蛋白和Cdc16 细胞分裂周期基因,显示出高度的进化保守性。通过调节Rab 蛋白的GTP-GDP 转换循环,TBC 蛋白在特异性细胞内运输中扮演着重要角色。它不仅在维持正常细胞生理过程中至关重要,而且其功能异常或突变与多种人类疾病的发生密切相关。该文综述了TBC 蛋白的结构特征、生化功能及在人类疾病中作用的最新研究成果,旨在深入理解其在疾病发展中的潜在机制。
通讯作者:任 骏 , Email:ren.jun@zs-hospital.sh.cn
Abstract:
TBC proteins, as Tre2-Bub2-Cdc16 (TBC) structural domain-containing GTPase activators, play a key role in the negative regulation of Rab proteins. This structural domain integrates the Tre2 proto-oncogene, the Bub2 yeast cell cycle regulatory protein, and the Cdc16 cell division cycle gene, showing a high degree of evolutionary conservation. By regulating the GTP-GDP transition cycle of Rab proteins, the TBC proteins play an important role in specific intracellular transport. It is not only essential in maintaining normal cellular physiological processes, but also its abnormal function or mutation is closely associated with the development of several human diseases. In this paper, we review the latest research results on the structural features, biochemical functions and roles of TBC proteins in human diseases, aiming to gain a deeper understanding of their potential mechanisms in disease development.
Communication Author:REN Jun , Email:ren.jun@zs-hospital.sh.cn