《生命科学》 2024, 36(7): 877-886

生物毒素抗病毒作用的研究进展

佘梓荧 , 曹　程 , 周　进^*

清华大学深圳国际研究生院，海洋工程研究院，深圳 518055

摘　要：

随着全球病毒多样性的增加和变异速度的加快，现有疫苗和抗病毒药物防控方法面临巨大挑战，因此急需开发新型抗病毒药物以缓解这一压力。在这种情况下，生物毒素的开发带来了曙光，各类生物毒素( 蜂毒、蛇毒、蝎毒、藻毒素等) 表现出很强的抗病毒活性，具有成为新型抗病毒药物的潜力。基于此，本文以近10 年的文献为重点，综述了主要天然毒素的有效成分、抗病毒机制和应用情况，并对生物毒素的成药机遇和挑战进行了展望。

通讯作者：周　进 , Email:zhou.jin@sz.tsinghua.edu.cn

Research progress of biotoxins in the antiviral field

SHE Zi-Ying , CAO Cheng , ZHOU Jin^*

Institute of Ocean Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China

Abstract:

With the increasing viral diversity and their mutation probability globally, the current methods (such as vaccines and antiviral therapies) are facing great challenges. Therefore, it is urgent for us to develop novel antiviral drugs. Under such circumstances, various types of biotoxins (for example bee venom, snake venom, scorpion venom, and algal toxins, etc.) show antiviral potential and can act as new candidates for antiviral drug resources. Based on this, we review the active ingredients, antiviral mechanisms, and possible applications of major biotoxins over the past 10 years. In addition, we provide an outlook on the opportunities and challenges of biotoxin drugs, hoping to gather new ideas for the development of antiviral drugs.

Communication Author：ZHOU Jin , Email:zhou.jin@sz.tsinghua.edu.cn