《生命科学》 2024, 36(6): 849-856

CMKLR1与抑郁障碍相关的研究进展

唐思嘉¹ , 陈　俊¹ , 方贻儒^1,2,*

¹上海交通大学医学院附属精神卫生中心临床研究中心，上海 200032 ²上海交通大学医学院附属瑞金医院精神心理科&情感障碍中心，上海 200025

摘　要：

抑郁障碍作为一种广泛影响全球人口的心理健康问题，引起了研究人员对其潜在生物学基础的兴趣。近年来，神经递质、神经回路和免疫系统在抑郁障碍中的作用研究不断增多。在这一背景下，CMKLR1(chemokine-like receptor 1) 作为一个新兴的研究方向引起了研究人员的关注。CMKLR1 最初被认为在免疫系统中发挥重要作用，然而最近的研究表明，它也可能与神经炎症的调节密切相关。本综述旨在深入探讨CMKLR1 与抑郁障碍之间的潜在关联，揭示其在疾病发生和发展中的可能机制，以及作为潜在治疗靶点的可能性。

通讯作者：方贻儒 , Email:yirufang@aliyun.com

Research progress on the association between CMKLR1 and depression

TANG Si-Jia¹ , CHEN Jun¹ , FANG Yi-Ru^1,2,*

¹Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China ²Department of Psychiatry & Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Abstract:

Depression, as a widespread mental health issue affecting the global population, has sparked interest among researchers in understanding its potential biological basis. In recent years, there has been a growing body of research on the roles of neurotransmitters, neural circuits, and the immune system in depression. Against this backdrop, CMKLR1 (chemokine-like receptor 1) emerged as a novel research focus. It was initially thought to play a crucial role in the immune system, but recent studies suggested a potential close connection between CMKLR1 and the regulation of neuroinflammation. This review aims to delve into the potential association between CMKLR1 and depression, uncovering its possible mechanisms in the onset and development of the disorder, as well as its potential as a therapeutic target.

Communication Author：FANG Yi-Ru , Email:yirufang@aliyun.com