《生命科学》 2024, 36(6): 818-830

O-GlcNAcylation对抗癌治疗效果的影响及其机制

马斌媛 , 高宏伟 , 尤崇革 , 潘云燕^*

兰州大学第二医院检验医学中心，兰州 730000

摘　要：

O- 连接-N- 乙酰氨基葡萄糖化 (O-linked β-N-acetylglucosamine, O-GlcNAcylation) 是蛋白质翻译后修饰 (protein translation modifications, PTMs) 的一种，调节各种基本的细胞生物学过程，包括基因转录、信号转导、应激反应和细胞代谢等。目前，O-GlcNAcylation 对肿瘤进展的影响已被认可，但其在抗癌疗效中的作用尚未被阐明。因此，本文旨在综述失调的O-GlcNAcylation 影响抗癌治疗效果的最新证据，分析O-GlcNAcylation 水平失调影响抗癌疗效的几种可能的机制，讨论靶向O-GlcNAcylation 作为癌症治疗增敏剂的可能性，为提高抗癌治疗效果提供理论参考。

通讯作者：潘云燕 , Email:pyyhbw@126.com

Implications and mechanisms of O-GlcNAcylation on anti-cancer therapy efficacy

MA Bin-Yuan , GAO Hong-Wei , YOU Chong-Ge , PAN Yun-Yan^*

Center for Laboratory Medicine, The Second Hospital of Lanzhou University, Lanzhou 730000, China

Abstract:

O-linked β-N-acetylglucosamine (O-GlcNAcylation) is one of the protein translation modifications (PTMs) that regulate a variety of fundamental cellular biological processes, including gene transcription, signal transduction, stress response and cell metabolism. The role of dysregulated O-GlcNAcylation in tumorigenesis has been recognized, but its role in the anti-cancer therapy efficacy has not been elucidated. Therefore, this article reviews the latest evidence that dysregulated O-GlcNAcylation affects anti-cancer therapy efficacy, analyzes several possible mechanisms by which dysregulated O-GlcNAcylation levels affect anti-cancer therapy efficacy, and discusses the possibility of targeting O-GlcNAcylation as a cancer therapeutic sensitizer, aiming to provide theoretical references to improve the efficacy of anti-cancer therapy.

Communication Author：PAN Yun-Yan , Email:pyyhbw@126.com