《生命科学》 2024, 36(6): 797-806

运动调节Hippo-YAP通路改善心力衰竭的分子机制研究进展

鞠文宇 , 陈志欣 , 张嘉敏 , 王友华^*

陕西师范大学体育学院，西安 710119

摘　要：

心力衰竭是严重影响全球生命健康的疾病之一，其病理发生发展过程与炎症浸润、能量代谢紊乱和线粒体功能障碍密切相关。Hippo-YAP 通路具有感知机械压力刺激，从而调控细胞增殖、分化和器官大小的生物学功能。运动作为一种简单易行且无副作用的非药物治疗手段，在调控免疫炎症反应和线粒体质量控制等方面发挥重要作用，有效抑制心力衰竭病理发展；研究发现，运动可能通过调节Hippo-YAP 通路来改善心力衰竭。该文综述了Hippo-YAP 通路与心力衰竭发生发展的生物学机制，进一步论述了运动调节Hippo-YAP 通路改善心力衰竭的分子机制，以期为预防和治疗心力衰竭提供新思路和理论依据。

通讯作者：王友华 , Email:wangyouh@snnu.edu.cn

Progress in the molecular mechanism of exercise modulation of the Hippo-YAP pathway to ameliorate heart failure

JU Wen-Yu , CHEN Zhi-Xin , ZHANG Jia-Min , WANG You-Hua^*

School of Physical Education, Shaanxi Normal University, Xi’an 710119, China

Abstract:

Heart failure is one of the most important diseases affecting global life and health. Its pathogenesis is closely related to the disorder of inflammatory infiltration, energy metabolism and mitochondrial function. The Hippo-YAP pathway has the biological function of sensing mechanical pressure to regulate cell proliferation and differentiation and organ size. Exercise, as a simple and easy non-pharmacological treatment without side effects, plays an important role in modulating immune-inflammatory responses and mitochondrial quality control, and effectively inhibits the development of heart failure pathology. It has been found that exercise may ameliorate heart failure by modulating the Hippo-YAP pathway. This paper reviews the biological mechanism of the Hippo-YAP pathway and the development of heart failure, and further discusses the molecular mechanism by which exercise regulates the Hippo-YAP pathway to improve heart failure, in order to provide new ideas and theoretical basis for the prevention and treatment of heart failure.

Communication Author：WANG You-Hua , Email:wangyouh@snnu.edu.cn