《生命科学》 2024, 36(6): 777-786

衰老与电离辐射损伤的关系进展

丁旭东 , 樊赛军 , 路　璐^*

中国医学科学院北京协和医学院放射医学研究所，天津市放射医学与分子核医学重点实验室，天津 300192

摘　要：

衰老是人体的正常生命现象，其过程会伴随着多种器官和系统功能的下降，进而引起相关疾病的发生。细胞衰老作为衰老的关键因素之一，在衰老过程中具有重要意义。随着科学技术的不断进步，医学影像已经成为全球最大的人造辐射源，放射治疗作为恶性肿瘤的辅助治疗手段之一，在杀伤肿瘤细胞的同时也对正常器官组织造成损伤。电离辐射通过诱导DNA 损伤改变细胞状态，导致细胞坏死、凋亡或衰老。因此，衰老与电离辐射损伤存在着联系。本综述主要论述了个体衰老和细胞衰老与辐射损伤的关系，总结了在不同组织器官中衰老和辐射损伤的相关机制，旨在为今后开展相关研究奠定基础，以更充分了解辐射对高龄人群的损伤机制。

通讯作者：路　璐 , Email:lulu@irm-cams.ac.cn

Study on the relationship of aging and ionizing radiation injury

DING Xu-Dong , FAN Sai-Jun , LU Lu^*

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

Abstract:

Aging is a normal life phenomenon in the human body, and its process is accompanied by a decline in the function of many organs and systems, which in turn causes the occurrence of related diseases. Cellular senescence, as one of the key factors of aging, is of great significance in the aging process. With the continuous progress of science and technology, medical imaging has become the world's largest source of man-made radiation. Radiation therapy, as one of the adjuvant treatments for malignant tumors, kills tumor cells while causing damage to normal organs and tissues. Ionizing radiation alters the cellular state by inducing DNA damage, leading to cell necrosis, apoptosis or senescence. Thus, senescence establishes a link with ionizing radiation damage. This review focuses on the relationship between individual senescence and cellular senescence and radiation injury, summarizes the relevant mechanisms of senescence and radiation damage in different tissues and organs, and aims to lay the foundation for future related studies to facilitate a full understanding of the mechanisms of radiation injury in the aging population.

Communication Author：LU Lu , Email:lulu@irm-cams.ac.cn