《生命科学》 2024, 36(6): 741-748

重新审视口腔鳞状细胞癌中的牙龈卟啉单胞菌

李晨曦^1,2 , 魏　巍¹ , 李慕秋¹ , 谭小容¹ , 周　朦¹ , 龚忠诚^1,*

¹新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科，新疆维吾尔自治区口腔医学研究所，乌鲁木齐 830054 ²华中科技大学同济医学院附属协和医院，口腔医学中心，口腔颌面发育与再生湖北省重点实验室，武汉 430022

摘　要：

口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC) 显著加剧了全球癌症负担。越来越多的证据表明，口腔菌群对OSCC 的发生发展起着重要作用。牙龈卟啉单胞菌作为成人慢性牙周炎的关键病原体，其致癌作用已被广泛证实。因此，亟须了解牙龈卟啉单胞菌在OSCC 中的发病基础。笔者通过收集和评估牙龈卟啉单胞菌参与OSCC 发病机制的科学证据，旨在重新认识OSCC 微环境中牙龈卟啉单胞菌的生物学表现及作用。

通讯作者：龚忠诚 , Email:gzc740904@xjmu.edu.cn

Reconsideration concerning the role of Porphyromonas gingivalis in oral squamous cell carcinoma: a narrative review

LI Chen-Xi^1,2 , WEI Wei¹ , LI Mu-Qiu¹ , TAN Xiao-Rong¹ , ZHOU Meng¹ , GONG Zhong-Cheng^1,*

¹Department of Oral and Maxillofacial Oncology & Surgery, the First Affiliated Hospital/Affiliated Stomatological Hospital of Xinjiang Medical University, Stomatological Research Institute of Xinjiang Uygur Autonomous Region, Urumqi 830054, China ²Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, School of Stomatology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China

Abstract:

Oral squamous cell carcinoma (OSCC) has significantly contributed to the global cancer burden. Based on an increasing number of evidence, oral bacteria play an important role in the occurrence and development of OSCC. As a key pathogen of chronic periodontitis, Porphyromonas gingivalis’s carcinogenic implications have been widely proven. It is imperative to understand the pathogenic basis of P. gingivalis in OSCC. In the review, we collect and evaluate the scientific shreds of proof on the involvement of P. gingivalis in the molecular mechanism of OSCC in order to reconsider its biological performance and effect.

Communication Author：GONG Zhong-Cheng , Email:gzc740904@xjmu.edu.cn