《生命科学》 2024, 36(5): 722-732

固态氢供体在医药和保健食品中应用的研究进展

曾　鑫¹ , 铁　起² , 王绪珍² , 刘健康¹ , 赵　琳^3,*

¹西安交通大学生命科学与技术学院，线粒体生物医学研究所，生物医学信息工程教育部重点实 验室，西安 710049 ²日照生命谷生物科技发展股份公司，日照 276800 ³西安交通大学第一附 属医院心血管内科，代谢性心血管疾病教育部医药基础研究创新中心，西安 710061

摘　要：

自从氢气广泛的生物活性被发现以来，氢生物医学的发展如火如荼。随着氢气在生物医学中的应用研究不断发展和深入，吸入氢气、饮用富氢水等常用摄入氢分子的途径因其不够便捷、无靶向性等缺陷一定程度上限制了氢分子生物医学的发展。固态氢供体因释氢量大、可控缓释、可靶向递送、便携等优点成为氢生物医学领域的新兴热点。该文从基于镁、钯、铁等的金属固态氢供体，基于硅的无机非金属固态氢供体和基于食品珊瑚钙及牡蛎钙的固态氢供体三个方面尽可能地对固态氢供体在医药和保健食品中应用的研究进展进行了梳理和综述。在金属基固态氢供体中，镁基固态氢供体研究较多，以镁基植入物和微马达为代表，钯基和铁基固态氢供体的应用则更侧重靶向控制；非金属硅基固态氢供体的优势在于实现了对氢原子较强还原性的利用；食品固态氢供体释氢量大、安全性高，有望尽早实现临床应用。

通讯作者：赵　琳 , Email:zhaolin2015@xjtu.edu.cn

Research progress on the application of solid hydrogen donor in medicine and health foods

ZENG Xin¹ , TIE Qi² , WANG Xu-Zhen² , LIU Jian-Kang¹ , ZHAO Lin^3,*

¹1Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ²Rizhao Life Valley Biotechnology Company, Rizhao 276800, China ³Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710061, China

Abstract:

Since the wide range of biological activities of hydrogen was discovered, the development of hydrogen biomedicine has been in full swing. With the continuous development and deepening of the research on the application of hydrogen in biomedicine, the common ways to ingest hydrogen molecules, such as inhaling hydrogen and drinking hydrogen-rich water, have limited the development of molecular hydrogen biomedicine to a certain extent due to their defects such as insufficient convenience and non-targeting nature. Due to the advantages of large amount of hydrogen release, controlled or sustained release of hydrogen, targeted delivery and portability, solid hydrogen donor has become a new hotspot in hydrogen biomedical research. In this paper, the research progress of the application of solid hydrogen donors in medicine and health foods was reviewed from three aspects: metal solid hydrogen donors based on magnesium, palladium, iron, etc., inorganic non-metal solid hydrogen donors based on silicon, and solid hydrogen donors based on foods like coral calcium and oyster calcium. Magnesium-based hydrogen donors have been reported in many studies with magnesium-based implants and micromotors as representatives. The applications of palladium-based and iron-based hydrogen donors are more focused on targeted control. The advantage of non-metallic   silicon based solid hydrogen donor is that it realizes the relatively strong reducibility of hydrogen atom. Food solid hydrogen donors are expected to  achieve clinical application soon because of their large amount of hydrogen  release and high safety.

Communication Author：ZHAO Lin , Email:zhaolin2015@xjtu.edu.cn