《生命科学》 2024, 36(5): 701-710

SIRT家族介导热量限制调控心血管疾病

张　慧 , 李婷婷 , 张铭宸 , 杜锦超 , 王孝文^* , 孙忠广^*

山东第二医科大学，潍坊 261053

摘　要：

心血管疾病是全球致死率最高的疾病，短期和长期热量限制(caloric restriction, CR) 均能够降低心血管疾病的发生率。SIRT 家族参与细胞内多种代谢，在减轻心脏炎症、氧化应激以及线粒体功能调节上起关键作用。该文就SIRT 家族在CR 改善各类心血管疾病中的作用和机制进行综述，并概述了热量限制模拟物通过SIRT 途径对心血管疾病的改善作用，为心血管疾病的早期防治和康复提供参考。

通讯作者：王孝文 , Email:wangxiaowen2003@126.com 孙忠广 , Email:sunzhongguang@outlook.com

Research progress on caloric restriction mediating the regulation of cardiovascular diseases by the SIRT family

ZHANG Hui , LI Ting-Ting , ZHANG Ming-Chen , DU Jin-Chao , WANG Xiao-Wen^* , SUN Zhong-Guang^*

Shandong Second Medical University, Weifang 261053, China

Abstract:

Cardiovascular disease is the disease with the highest mortality rate in the world. Both short-term and ong-term caloric restriction (CR) can reduce the incidence of cardiovascular disease. The SIRT family is involved in various intracellular metabolisms and plays a key role in reducing cardiac inflammation, oxidative stress and regulating mitochondrial function. This article reviews the role and mechanism of the SIRT family in the improvement of various cardiovascular diseases by CR, and outlines the improvement effect of caloric restriction mimetics on cardiovascular diseases through the SIRT pathway, providing a  reference for the early prevention, treatment and rehabilitation of cardiovascular diseases.

Communication Author：WANG Xiao-Wen , Email:wangxiaowen2003@126.com SUN Zhong-Guang , Email:sunzhongguang@outlook.com