《生命科学》 2024, 36(5): 684-690
虫草素在骨骼肌损伤修复中的作用研究进展
摘 要：
骨骼肌占机体体重的40%，是人体运动系统的重要器官，骨骼肌受损会严重影响人们正常的生活质量。目前研究发现氧化应激、炎症、线粒体紊乱和钙离子失衡等因素会严重影响骨骼肌的正常生理功能。因此，寻求药物促进骨骼肌再生修复和维持肌肉功能至关重要。虫草素是蛹虫草的主要活性成分，多项研究显示虫草素在促进骨骼肌功能方面具有巨大潜力。因此，本文梳理并综述了虫草素在骨骼肌损伤修复中的作用，如抗炎、抗氧化、调节线粒体功能等，以期为深入研究和开发虫草素保健品和药物并用于治疗骨骼肌损伤提供思路和理论支撑。
通讯作者：姚丽华 , Email:yaolh7905@163.com
Abstract:
Skeletal muscle, which accounts for 40% of body weight, is a vital component of the human locomotor system. Skeletal muscle damage can significantly impact people’s overall quality of life. Current research has found that the normal physiological function of skeletal muscle is significantly impacted by oxidative stress, inflammation, mitochondrial disorders, and calcium ion imbalance. Therefore, it is crucial to search for medications that promote skeletal muscle regeneration and repair, as well as maintain muscle function. Cordycepin is the primary active compound in Cordyceps militaris, which was reported to show significant potential in promoting skeletal muscle
function. Therefore, cordycepin may play an important role in the recovery of skeletal muscle injury. This paper provides a review of the role of cordycepin in the repair of skeletal muscle injury, including notable antiinflammatory effects, antioxidant activities, and regulation of mitochondrial function and so on. It would provide ideas and theoretical support for further studying and developing cordycepin-based food, healthcare products or drugs for skeletal muscle injury treatment.
Communication Author：YAO Li-Hua , Email:yaolh7905@163.com
