《生命科学》 2024, 36(5): 676-683

Nrf2调控的铁死亡通路在有氧运动预防肌少症中的研究进展

温小龙^1,2 , 刘玉倩² , 郭文闪³ , 翁锡全^4,* , 王海涛^2,*

¹广州体育学院研究生院，广州 510500 ²岭南师范学院运动与健康研究所，湛江 524048 ³华南师范大学体育科学学院，广州 510006 ⁴广州体育学院运动与健康学院，广州 510500

摘　要：

肌少症作为一种与增龄性衰老相关的骨骼肌疾病，伴随着骨骼肌质量、力量、功能的下降。全球目前有超过5 000 万肌少症患者，随着全球老龄化加剧，肌少症发生率会持续增加。研究表明，以脂质过氧化反应为主要生化特征的铁死亡与肌少症的发生相关。运动干预是目前防治肌少症的有效手段，其可能机制为核因子E2 相关因子2 (Nrf2) 通过调控铁代谢相关蛋白表达而影响机体铁水平，避免铁死亡。该文通过梳理国内外相关研究，探讨肌少症与铁死亡的关系以及有氧运动对Nrf2 调控的铁代谢及肌少症的影响，以期为预防和治疗肌少症提供新的作用靶点和理论依据。

通讯作者：翁锡全 , Email:xqweng2003@163.com 王海涛 , Email:haitaoyq@126.com

Research progress on the Nrf2-regulated ferroptosis pathway in the prevention of sarcopenia by aerobic exercise

WEN Xiao-Long^1,2 , LIU Yu-Qian² , GUO Wen-Shan³ , WENG Xi-Quan^4,* , WANG Hai-Tao^2,*

¹Graduate Department of Guangzhou Sport University, Guangzhou 510500, China ²Institute of Exercise and Health Promotion, Lingnan Normal University, Zhanjiang 524048, China ³School of Physical Education and Sport Science, South China Normal University, Guangzhou 510006, China ⁴School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China

Abstract:

As a skeletal muscle disease associated with aging,  sarcopenia is accompanied by a decline in skeletal muscle mass, strength, and function. More than 50 million people worldwide suffer from sarcopenia, and the  incidence of sarcopenia will continue to increase as the world ages. Recent studies have shown that ferroptosis with lipid peroxidation as the main biochemical characteristic is related to the occurrence of sarcopenia. Exercise intervention is currently an effective means of combating sarcopenia, and the possible mechanism is that nuclear factor E2-related factor 2 (Nrf2) affects the body’s iron level by regulating the expression of proteins related to iron metabolism, thus avoiding ferroptosis. In this review, we based on relevant domestic and foreign studies explore the relationship between sarcopenia and  ferroptosis, the effects of aerobic exercise on iron metabolism and sarcopenia regulated by Nrf2, with the aim of providing new targets and theoretical basis for the prevention and treatment of sarcopenia.

Communication Author：WENG Xi-Quan , Email:xqweng2003@163.com WANG Hai-Tao , Email:haitaoyq@126.com