《生命科学》 2024, 36(5): 649-657

非编码RNA通过调控Notch通路影响非小细胞肺癌的生物学行为

孙佳珺¹ , 董美辰¹ , 张树冰^2,* , 文斗斗^2,*

¹中南大学湘雅医学院，长沙 410013 ²中南大学生命科学学院细胞生物学系，长沙 410013

摘　要：

Notch 信号通路是决定细胞命运的重要通路之一，已被证实在非小细胞肺癌(NSCLC) 的增殖、分化和凋亡中起重要作用。在对Notch 信号通路与NSCLC 的研究中，非编码RNA (ncRNA) 对Notch 通路的调控是近五年的一个研究热点。其中，微小RNA (miRNA)、长链非编码RNA (lncRNA) 和环状RNA (circRNA)通过多种方式调控Notch 通路从而影响NSCLC 的发生发展。此外，ncRNA 对Notch 通路的调控还与NSCLC 耐药相关。尽管目前ncRNA 在NSCLC 治疗中的研究较少，但是基于ncRNA 的靶向药物将为NSCLC 治疗提供新的方案。

通讯作者：张树冰 , Email:shubingzhang@csu.edu.cn 文斗斗 , Email:doudou_wen@csu.edu.cn

Non-coding RNAs affect the biological behaviors of non-small cell lung cancer by regulating the Notch signaling pathway

SUN Jia-Jun¹ , DONG Mei-Chen¹ , ZHANG Shu-Bing^2,* , WEN Dou-Dou^2,*

¹Xiangya School of Medicine, Central South University, Changsha 410013, China ²Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, China

Abstract:

Notch signaling pathway is one of the important  pathways determining cell fate and has been widely studied and confirmed to play pivotal roles in  proliferation, differentiation and apoptosis of non-small cell lung cancer (NSCLC). In the study of Notch signaling pathway and NSCLC, the regulation of Notch pathway by non-coding RNAs (ncRNAs) has become a research  hotspot in the last five years, among which microRNAs
(miRNAs), long chain non-coding RNAs (lncRNAs) and  circular RNAs (circRNAs) can affect the progression of NSCLC by regulating the Notch pathway in various ways.  In addition, the regulation of Notch pathway by ncRNAs
is also associated with drug resistance in NSCLC.  Although there are fewer studies on ncRNAs in NSCLC  reatment, ncRNA-based targeted drugs will provide new options for NSCLC treatment.

Communication Author：ZHANG Shu-Bing , Email:shubingzhang@csu.edu.cn WEN Dou-Dou , Email:doudou_wen@csu.edu.cn