《生命科学》 2024, 36(5): 637-648

非受体型蛋白酪氨酸磷酸酶2在肿瘤免疫中的研究进展

李慧芸^1,2 , 姜凯龙^2,* , 李　佳^1,2,*

¹遵义医科大学药学院，遵义 563006 ²中科中山药物创新研究院，中山 528400

摘　要：

非受体型蛋白酪氨酸磷酸酶2 (protein tyrosine phosphatase non-receptor type 2, PTPN2) 作为蛋白酪氨酸磷酸酶家族成员，通过催化去磷酸化反应，在细胞信号传递中起着重要作用。PTPN2 过表达与多种癌症患者预后不良密切相关，而其缺失能有效抑制肿瘤的增长、迁移，并促进细胞凋亡。在免疫系统中，PTPN2 在T 细胞功能以及肿瘤微环境的调节中起着关键作用。因此，PTPN2 在肿瘤发展过程和肿瘤免疫中扮演了重要角色，是一个潜在抗肿瘤新靶点。目前， 有多个PTPN2 抑制剂或降解剂被发现，其中两个抑制剂已进入临床I 期试验阶段。该文综述了PTPN2 的结构特性、在抗肿瘤免疫中的功能与应用，以及当前对其抑制剂和降解剂在肿瘤治疗中的研究进展。

通讯作者：姜凯龙 , Email:jiangkailong@zidd.ac.cn 李　佳 , Email:jli@simm.ac.cn

Research advances of protein tyrosine phosphatase non-receptor type 2 in tumor immunity

LI Hui-Yun^1,2 , JIANG Kai-Long^2,* , LI Jia^1,2,*

¹School of Pharmacy, Zunyi Medical University, Zunyi 563006, China ²Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China

Abstract:

Protein tyrosine phosphatase non-receptor type 2  (PTPN2), a member of the protein tyrosine phosphatase
family, plays an important role in cellular signaling by catalyzing dephosphorylation reactions. Overexpression of PTPN2 is closely associated with poor prognosis of patients with various cancers. And its absence can effectively inhibit tumor growth, migration, and promote apoptosis. In the immune system, PTPN2 plays a key role in the regulation of T cell function and tumor  microenvironment. Therefore, PTPN2 plays an important role in tumor development and tumor immunity, and is a potential new anti-tumor target. Currently, several PTPN2 inhibitors or degraders have been identified, and two of them have  entered phase I clinical trials. In this paper, we review the structural properties of PTPN2, its functions and  applications in anti-tumor immunity, and the current progress of research on its inhibitors and degraders in tumor therapy.

Communication Author：JIANG Kai-Long , Email:jiangkailong@zidd.ac.cn LI Jia , Email:jli@simm.ac.cn