《生命科学》 2024, 36(4): 537-553

支链氨基酸在运动改善胰岛素抵抗中的作用研究进展

曹　维^1,2 , 魏　昊^1,2 , 郜瑞睿^1,2 , 孙海鹏^3,4 , 邱俊强^1,2,*

¹北京体育大学运动人体科学学院，运动生物化学教研室，北京 100084 ²运动营养北京市高等学校工程研究中心，北京 100084 ³天津医科大学朱宪彝纪念医院&内分泌研究所，天津市代谢性疾病重点实验室，国家卫生健康委员会激素与发育 重点实验室，天津 300134 ⁴天津医科大学医学表观遗传学省部共建协同创新中心，心血管病中心，天津 300134

摘　要：

作为必需氨基酸，支链氨基酸(branched chain amino acids, BCAAs) 是一种被广泛应用的运动营养补剂。然而越来越多的证据表明，BCAAs 与胰岛素抵抗(insulin resistance, IR) 之间密切相关，BCAAs 分解代谢能力受损是高水平BCAAs 的主要原因。运动是有效预防和缓解IR 的非药物手段，急性运动和长期运动可能通过不同的调节因子来增强BCAAs 分解代谢以减轻BCAAs 堆积，促进BCAAs 稳态的恢复。本文将针对运动对BCAAs 的作用和可能机制以及运动通过BCAAs 改善IR 的研究现状进行综述，旨在为IR 人群制定运动营养干预策略提供新思路。

通讯作者：邱俊强 , Email:qiujunqiang@bsu.edu.cn

Research progress on the role of branched-chain amino acids in the improvement of insulin resistance by exercise

CAO Wei^1,2 , WEI Hao^1,2 , GAO Rui-Rui^1,2 , SUN Hai-Peng^3,4 , QIU Jun-Qiang^1,2,*

¹Department of Exercise Biochemistry, School of Sports Science, Beijing Sport University, Beijing 100084, China ²Beijing Sports Nutrition Engineering Research Center, Beijing 100084, China ³NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China ⁴Center for Cardiovascular Diseases, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300134, China

Abstract:

Branched chain amino acids (BCAAs) as essential amino acids are popular sports nutrition supplements. However, an increasing amount of evidence suggests that BCAAs are strongly associated with insulin resistance (IR), and impaired BCAAs catabolism is an important contributor to high levels of BCAAs. Exercise is an effective non-pharmacological approach to the prevention and alleviation of metabolic diseases. Acute and long-term exercise participate in exercise-enhanced BCAAs catabolism to attenuate BCAAs accumulation and promote the recovery of BCAAs homeostasis through various regulatory factors, respectively. This review summarizes the current state of research on the effects and possible mechanisms of exercise-mediated BCAAs, as well as exercise amelioration of IR through BCAAs, with the aim of providing new ideas for the development of sports nutrition intervention strategies for the IR population.

Communication Author：QIU Jun-Qiang , Email:qiujunqiang@bsu.edu.cn