《生命科学》 2024, 36(4): 527-536

果糖激酶的研究进展

李雨佳¹ , 王　丽² , 张　策^3,* , 赵乃倩^2,*

¹山西医科大学第二临床医学院内分泌科，太原 030001 ²山西医科大学第二医院 老年科，太原 030001 ³山西医科大学基础医学院，太原 030001

摘　要：

果糖激酶(KHK) 是果糖分解代谢的限速酶，有果糖激酶C(KHK-C) 和果糖激酶A(KHK-A) 两种剪接变体。KHK-C 是果糖分解代谢功能的主要承担者，并且通过其蛋白质乙酰化作用，促使果糖的代谢产物更多地用于甘油三酯的合成，是果糖相关代谢性疾病的根本原因。KHK 还在多种肿瘤的生长、增殖和转移中发挥重要作用。KHK-C 可激活与代谢重编程有关的信号通路和代谢通路，KHK-A 则是作为一种丝氨酸/苏氨酸蛋白激酶，通过激活不同的信号转导分子或代谢通路的限速酶，促进肿瘤的生长、增殖和转移。该文就KHK 的结构、分布、调节、功能及与临床疾病的相关性进行综述，以期为后续研究提供理论依据。

通讯作者：张　策 , Email:1951584811@qq.com 赵乃倩 , Email:407288101@qq.com

Research progress of ketohexokinase

LI Yu-Jia¹ , WANG Li² , ZHANG Ce^3,* , ZHAO Nai-Qian^2,*

¹Department of Endocrinology, The Second Clinical College of Medicine of Shanxi Medical University, Taiyuan 030001, China ²Department of Geriatric, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China ³Basic Medical College of Shanxi Medical University, Taiyuan 030001, China

Abstract:

Ketohexokinase (KHK), the rate-limiting enzyme in the first step of fructose metabolism, exists in two alternatively spliced isoforms of ketohexokinase C (KHK-C) and ketohexokinase A (KHK-A). KHK-C is the main undertaker of fructose catabolism, and through its protein acetylation, fructose metabolites are more used in the synthesis of triglycerides, which is the root cause of fructose-related metabolic diseases. Moreover, KHK also plays an important role in the growth, proliferation and metastasis of many different types of cancers. KHK-C triggers a reprogrammed transcriptional and metabolic profile, while KHK-A acts as a serine or threonine protein kinase, phosphorylating and activating different signaling molecules or some rate-limiting enzyme to facilitate tumor growth, proliferation and metastasis. This article reviews the structure, distribution, regulation, function, and correlation with clinical diseases of KHK, in order to provide a theoretical foundation for further researches.

Communication Author：ZHANG Ce , Email:1951584811@qq.com ZHAO Nai-Qian , Email:407288101@qq.com