《生命科学》 2024, 36(4): 477-486

小胶质细胞调节孤独症谱系障碍的作用机制研究进展

马如意 , 范广祥 , 陈依文 , 姜泊远 , 吴　悠 , 陈雨珊^*

武汉科技大学医学院，脑科学先进技术研究院，武汉 430065

摘　要：

孤独症谱系障碍(autism spectrum disorder, ASD) 是一种神经发育障碍，其特征是社会交流障碍和限制性重复行为。神经和免疫系统功能障碍被认为是ASD 的根本发病原因。大脑常驻免疫细胞—— 小胶质细胞参与ASD 的发病机制，因此小胶质细胞功能障碍与ASD 之间的关系值得深入探究。本文主要探讨小胶质细胞在神经发育中的作用，重点分析小胶质细胞在ASD 中的神经调控作用，总结靶向小胶质细胞治疗ASD 的研究现状，为ASD 的治疗干预提供理论依据和潜在靶标。

通讯作者：陈雨珊 , Email:yschen@wust.edu.cn

Advances in regulatory roles and mechanisms of microglia in autism spectrum disorders

Ma Ru-Yi , Fan Guang-Xiang , Chen Yi-Wen , Jiang Bo-Yuan , Wu You , Chen Yu-Shan^*

(Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China

Abstract:

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted or repetitive behaviors. Neurological and immune system dysfunctions are considered to be fundamental causes of ASD. Studies have shown that microglia, the brain's resident immune cells, are a possible key player in ASD. Therefore, the relationship between microglia dysfunction and ASD is worth further exploration. This review mainly discusses the role of microglia in neurodevelopment, analyzes the neuroregulatory role of microglia in ASD, summarizes the current studies on targeting microglia to alleviate ASD, and provides theoretical basis and potential targets for therapeutic intervention of ASD.

Communication Author：Chen Yu-Shan , Email:yschen@wust.edu.cn