《生命科学》 2024, 36(4): 456-466

PrP^C在脑缺血中的作用

王　月^1,2 , 王　可³ , 尚文豆^1,2 , 刘怀玉^1,2 , 张文欣^1,2 , 何　治^1,2,3,*

¹三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002 ²三峡大学健康医学院，宜昌 443002 ³嘉兴学院医学院，嘉兴 314000

摘　要：

细胞朊病毒蛋白(PrP^C) 是一种高度保守的细胞表面糖蛋白，具有多种配体并在许多组织和细胞亚型中不同程度地表达，在中枢神经系统(CNS) 中高表达。研究发现PrP^C 可通过减轻兴奋性毒性、炎症反应、氧化应激、凋亡以及促进神经再生及血管生成来减轻缺血性脑损伤。该文对PrP^C 的基础信息、生理病理作用及在脑缺血中的作用机制进行综述，以期为防治脑缺血提供研究基础。

通讯作者：何　治 , Email:17381350209@163.com

The role of PrP^C in cerebral ischemia

WANG Yue^1,2 , WANG Ke³ , SHANG Wen-Dou^1,2 , LIU Huai-Yu^1,2 , ZHANG Wen-Xin^1,2 , HE Zhi^1,2,3,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China ²Health Medical College, China Three Gorges University, Yichang 443002, China ³Jiaxing University School of Medicine, Jiaxing 314000, China

Abstract:

Cellular prion protein (PrP^C) is a highly conserved cell surface glycoprotein with multiple ligands and is expressed in many tissues and cell subtypes to varying degrees, and is highly expressed in the central nervous system (CNS). Studies have found that PrP^C can alleviate ischemic brain injury by reducing excitatory toxicity, inflammatory response, oxidative stress, apoptosis, and promoting nerve regeneration and angiogenesis. Therefore, this review aims to provide an overview of the fundamental knowledge of PrP^C, its physiological and pathological functions, and the mechanisms by which it exerts its effects on the brain in ischemic conditions. This information is essential for the development of effective strategies for the prevention and treatment of ischemic brain injury.

Communication Author：HE Zhi , Email:17381350209@163.com