《生命科学》 2024, 36(3): 360-372

CAR-T免疫细胞疗法在抗病毒感染中的研究进展

项诗棋¹ , 王嘉元¹ , 孙健红^1,2,* , 张同存^1,*

¹武汉科技大学生命科学与健康学院，武汉 430065 ²重庆黔江武陵山生物医药联合研究院，重庆 401338

摘　要：

目前，世界上大多数病毒感染没有针对性的特效药，尤其是具有潜伏感染能力的病毒，如乙型肝炎病毒(hepatitis B virus, HBV)、巨细胞病毒(cytomegalovirus, CMV)、Epstein-Barr 病毒(epstein-barr virus, EBV)、人类免疫缺陷病毒(human immunodeficiency virus, HIV) 等，严重威胁人类健康。这些病毒感染宿主细胞后，与宿主蛋白互作，导致宿主细胞在其表面表达一些特异性的感染或潜伏标志蛋白，可以成为CAR-T 细胞疗法(chimeric antigen receptor T-cell immunotherapy, CAR-T) 的靶点，为难治性病毒性疾病的治愈提供了新的方向。

通讯作者：孙健红 , Email:sunjianhong0604@sina.com 张同存 , Email:zhangtongcun@wust.edu.cn

Research progress in CAR-T immunotherapy for antiviral infections

XIANG Shi-Qi¹ , WANG Jia-Yuan¹ , SUN Jian-Hong^1,2,* , ZHANG Tong-Cun^1,*

¹College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, China ²Chongqing Qianjiang Wuling Mountain Joint Academy of Biomedicine, Chongqing 401338, China

Abstract:

At present, most viral infections in the world have no miracle drugs, especially viruses with latent
infection ability, such as hepatitis B virus (HBV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), etc., which seriously threaten human health. After infecting host cells, these viruses interact with host proteins, causing host cells to express some specific infectious or latent marker proteins on cell surface, which can become targets of CAR-T therapy, providing a new direction for the cure of refractory viral diseases.

Communication Author：SUN Jian-Hong , Email:sunjianhong0604@sina.com ZHANG Tong-Cun , Email:zhangtongcun@wust.edu.cn