《生命科学》 2024, 36(3): 343-352

N⁶-甲基化腺苷修饰在乳腺癌中的研究进展

马　唯¹ , 吴宇丹² , 张红艳³ , 李彦姝^3,*

¹中国医科大学口腔医学院，沈阳 110122； ²中国医科大学护理学院，沈阳 110122 ³中国医科大学生命科学学 院分子细胞生物学教研室，教育部医学细胞生物学重点实验 室暨卫健委细胞生物学重点实验室，沈阳 110122

摘　要：

表观遗传学在乳腺癌的恶性进展中起到重要作用，其中N⁶- 甲基化腺苷(m⁶A) 修饰是最丰富的RNA 修饰，参与调节乳腺癌细胞恶性行为的通路及癌细胞所处的肿瘤微环境。同时，乳腺癌发病率居于我国女性恶性肿瘤首位，近年来首次发病年龄趋于年轻化，是严重危及我国女性健康的疾病之一。然而，乳腺癌早期治疗预后较好。当晚期出现转移后，患者5 年生存率差。m⁶A 作为一种可能用于乳腺癌早筛的生物标志物及新的药物治疗靶点，给乳腺癌的早期治疗提供了新的研究方向。本文系统地综述了m⁶A 修饰相关因子及其在乳腺癌恶性行为中发挥的调控作用，并列出现已知的一些靶向药物和潜在的早筛方法，为乳腺癌的诊断、治疗、监测提供新的思路。

通讯作者：李彦姝 , Email:yslcmu@163.com

Research progress of N⁶-methyladenine modifications in breast cancer

MA Wei¹ , WU Yu-Dan² , ZHANG Hong-Yan³ , LI Yan-Shu^3,*

¹School of Stomatology, China Medical University, Shenyang 110122, China ²Nursing School, China Medical University, Shenyang 110122, China ³Department of Cell Biology, Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, China Medical University, Shenyang 110122, China

Abstract:

Epigenetics plays important role in regulating the malignant progress of breast cancer, where N⁶-methyladenine (m⁶A) is the richest modification of RNA, taking part in many signaling pathways and influencing the tumor microenvironment. Breast cancer is the most common malignant tumors in Chinese women, which has a good prognosis after treatment at an early stage but a low five-year survival rate when metastasis occurs. As a new biomarker of screening breast cancer at early stage and a possible medicine target, m⁶A provides multiple ideas for the development of early treatment of breast cancer. This paper systematically reviews regulatory functions of m⁶A related molecules in different malignant behaviors, and additionally list some target drugs and possible measures to screen breast cancer, providing new ideas to diagnosis, treat and monitor breast cancer.

Communication Author：LI Yan-Shu , Email:yslcmu@163.com