《生命科学》 2024, 36(3): 333-342

细胞外囊泡参与T细胞耗竭机制的研究进展

代明珠¹ , 余卫平^1,* , 薛　明^2,*

¹东南大学医学院病理生理学系，南京 210009 ²东南大学附属中大医院重症医学科，南京 210009

摘　要：

细胞外囊泡(extracellular vesicles, EVs) 是指由各种细胞释放的脂质双层膜结构，可携带不同物质参与机体的病理生理过程。T 细胞耗竭(T cell exhaustion, TCE) 是指抗原刺激和( 或) 炎症持续存在造成T细胞分化、数量与质量异常改变，出现以耗竭T 细胞(exhausted T cells, Tex cells) 表现为主要特征的反应状态。EVs 携带的信号分子能参与T 细胞耗竭过程。本文综合评述了EVs在T 细胞耗竭机制中的作用及潜在的临床应用价值。

通讯作者：余卫平 , Email:yuweiping@seu.edu.cn 薛　明 , Email:Xueming0304@126.com

The role of extracellular vesicles in the mechanism of T cell exha

DAI Ming-Zhu¹ , YU Wei-Ping^1,* , XUE Ming^2,*

¹Department of Pathophysiology, School of Medicine, Southeast University, Nanjing 210009, China ²Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China

Abstract:

Extracellular vesicles (EVs) are lipid structures with bilayer membrane released by various cells which carry different substances to participate in the pathophysiological processes of the body. T cell exhaustion (TCE) refers to the exhausted T cells (Tex cells) response upon sustained antigen stimulation and/or inflammation, resulting in abnormal changes in T cell differentiation, quantity and quality. The signaling molecules carried by EVs are involved in the process of TCE. This article comprehensively reviews the role of EVs in the mechanism of TCE and their potential clinical application value.

Communication Author：YU Wei-Ping , Email:yuweiping@seu.edu.cn XUE Ming , Email:Xueming0304@126.com