《生命科学》 2024, 36(3): 285-290

氯通道膜蛋白内部Cl^-/H⁺耦合转运机制研究进展

向泽雨¹ , 王　哲² , 于　涛^1,3,*

¹江汉大学光电材料与技术学院，武汉 430056 ²江汉大学医学院， 武汉 430056 ³光电化学材料与器件教育部重点实验室，武汉 430056

摘　要：

氯通道是细胞膜上一类离子选择性跨膜蛋白，其功能是调节细胞内部溶液pH、细胞容积、盐类离子转运以及细胞电兴奋性。按照离子输运方式的差异，氯通道膜蛋白可分为氯离子通道和Cl^-/H⁺转运体两类，其中Cl^-/H⁺ 转运体内部的离子转运过程具有显著耦合性，且该过程需要借助水分子参与。本文针对Cl^-/H⁺耦合转运微观机制研究进行总结及展望，为氯通道实验研究、临床疾病诊治和新药研发提供理论依据。

通讯作者：于　涛 , Email:tyu@jhun.edu.cn

Research progress on Cl^-/H⁺ coupling transport mechanism in chloride channel membrane proteins

XIANG Ze-Yu¹ , WANG Zhe² , YU Tao^1,3,*

¹School of Optoelectronic Materials and Technology, Jianghan University, Wuhan 430056, China ²School of Medicine, Jianghan University, Wuhan 430056, China ³Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Wuhan 430056, China

Abstract:

Chloride channels are one kind of ion selective transmembrane proteins. Their functions are regulating intracellular solution pH, cell volume, salt ion transport and cell excitability. According to difference of ion transport modes, chloride channel membrane proteins can be divided into chloride ion channel and Cl^-/H⁺ transporter. Among them, ionic transport process in Cl^-/H⁺ transporter shows significant coupling, and needs the participation of water molecules. In this paper, we summarize and prospect the microscopic coupling transport mechanism of Cl^-/H⁺, which can provide theoretical basis for experimental research of chloride channels, clinical disease diagnosis and treatment and new drug development.

Communication Author：YU Tao , Email:tyu@jhun.edu.cn