《生命科学》 2024, 36(1): 11-20

2023年计算生物学科技发展态势

毛开云¹ , 江　源¹ , 袁银池¹ , 张　华² , 周丽萍³ , 江洪波^1,4,*

¹中国科学院上海生命科学信息中心，中国科学院上海营养与健康研究所，上海 200031 ²上海市生物医药科技发 展中心，上海 201203 ³上海生物医药公共技术服务有限公司，上海 201203 ⁴中国科学院大学，北京 100049

摘　要：

    计算生物学借助大量生物数据的模拟与分析，探寻生物体及生态系统的结构和功能，从而加深对生物体的认识与理解。得益于算法的持续优化和计算机性能的提高，计算生物学逐步克服了大量数据处理和分析的难题。2023 年，计算生物学在基因组学、蛋白质结构解析与预测、药物研发、疾病诊断与预测等多个应用领域取得突破性进展。随着技术的进步和数据的积累，计算生物学在未来的发展前景非常广阔，但仍存在数据质量问题、算法和模型复杂度、实验验证的难度、多学科交叉融合的挑战，以及伦理和社会问题等诸多难点需突破。

通讯作者：江洪波 , Email:hbjiang@sinh.ac.cn

The technological development trends of computational biology in 2023

MAO Kai-Yun¹ , JIANG Yuan¹ , YUAN Yin-Chi¹ , ZHANG Hua² , ZHOU Li-Ping³ , JIANG Hong-Bo^1,4,*

¹Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Science, Shanghai 200031, China ²Shanghai Center of Biomedicine Development, Shanghai 201203, China ³Shanghai Biopharma Service Co.,Ltd, Shanghai 201203, China; ⁴University of Chinese Academy of Sciences, Beijing 100049, China

Abstract:

    Computational biology simulates and analyzes a large amount of biological data to discover the structure and function of organisms and ecosystems, deepening our understanding and comprehension of organisms. Thanks to the continuous optimization of algorithms and the improvement of computer performance, computational biology has gradually overcome the challenges of massive data processing and analysis. In 2023, computational biology has made breakthrough progress in multiple application fields such as genomics, protein structure analysis and prediction, drug development, disease diagnosis and prediction. With the advancement of technology and the accumulation of data, computational biology has a very broad development prospect in the future. However, there are still many difficulties that need to be overcome, such as data quality issues, algorithm and model complexity, difficulty in experimental verification, challenges in interdisciplinary integration, ethical and social issues, and so on.

Communication Author：JIANG Hong-Bo , Email:hbjiang@sinh.ac.cn