《生命科学》 2024, 36(1): 2-10

2023年整合生物学领域发展态势

张学博¹ , 孟　晶² , 刘　晓¹ , 朱成姝¹ , 江　源¹ , 阮梅花¹ , 熊　燕^1,3 , 陈大明^1,3,*

¹中国科学院上海生命科学信息中心，中国科学院上海营养与健康研究所，上海 200031 ²同济大学附属第一妇婴保健院，上海 200092 ³中国科学院大学，北京 100049

摘　要：

    自20 世纪中叶以来，生命科学研究逐渐从单一的生物个体水平延伸到细胞、分子、基因等不同层次。面对生物体的复杂性和多样性，跨层级、多维度、全周期的生命结构与功能研究日益受到重视，整合生物学应运而生，旨在揭示生物体内部各种层次之间的相互关系和调控机制，以期深入了解生物体的功能和行为。回顾数十年整合生物学的发展历程，多学科交叉的工具为其提供了有力的支撑，跨层级的功能涌现现象是其研究的关键节点，其理论基础则在于揭示了非线性、不确定性和异质性等复杂科学特征，为生命健康解决方案的赋能提供了基础。2023 年，整合生物学在研究生命系统的涌现现象、健康及生态环境方面取得了突破性进展，加深了我们对生命系统整体知识体系的理解，也促进了对生物体在健康和疾病状态下的生理和病理变化的全面了解。展望未来，整合生物学或将以更为综合的整体视角，深入解析生命系统的复杂性、临界条件的变化、无序与有序状态的转化过程，进而促进人类对于生命本质的更深认知，创新前所未有的技术策略。

通讯作者：陈大明 , Email:chendaming@sinh.ac.cn

Development trend of integrative biology field in 2023

ZHANG Xue-Bo¹ , MENG Jing² , LIU Xiao¹ , ZHU Cheng-Shu¹ , JIANG Yuan¹ , RUAN Mei-Hua¹ , XIONG Yan^1,3 , CHEN Da-Ming^1,3,*

¹Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China ²Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China ³University of Chinese Academy of Sciences, Beijing 100049, China

Abstract:

    Since the mid-20th century, life science research has gradually extended from the individual organism level to different levels such as cells, molecules, and genes. Faced with the complexity and diversity of living organisms, there is an increasing emphasis on cross-level, multidimensional, and lifelong structural and functional studies in life sciences. The emergence of integrative biology aims to reveal the relationships and regulatory mechanisms among various levels within organisms, with the goal of gaining a deeper understanding of the functions and behaviors of living organisms. Looking back on the decades-long development of integrative biology, interdisciplinary tools have provided robust support, and the emergence of cross-level functionalities has been a key juncture in its research. The revelation of scientific complexities such as non-linearity, uncertainty, and heterogeneity serves as the theoretical foundation that empowers solutions for life and health challenges. In 2023, integrative biology achieved remarkable breakthroughs in exploring emergent phenomena, health, and ecological environments within life systems. These advancements not only enhanced our comprehensive understanding of the life sciences but also facilitated a thorough grasp of the physiological and pathological changes in organisms, encompassing both states of health and disease. Looking ahead, integrative biology may, with its more comprehensive perspective, delve into the complexity of life systems, variations in critical conditions, and the transitions between  unordered and ordered states. This, in turn, may facilitate a deeper human understanding of the essence of life, fostering unprecedented technological strategies.

Communication Author：CHEN Da-Ming , Email:chendaming@sinh.ac.cn