《生命科学》 2023, 35(12): 1652-1659

免疫检查点LAG-3在抗肿瘤免疫治疗中的研究进展

陈锦辉¹ , 刘世文¹ , 何庆希¹ , 赖官喜² , 邵红伟¹ , 刘　松^1,2,3,*

¹广东省生物技术候选药物研究重点实验室，广州 510006 ²广东药科大学药学院、临床药学院(整合药学院)， 广州 510006 ³广东药科大学附属第一医院临床药学重点专科，临床精准用药研究中心，广州 510080

摘　要：

淋巴细胞活化基因-3 (LAG-3) 是继程序性死亡受体-1 (PD-1) 和细胞毒性T 淋巴细胞相关蛋白4(CTLA-4) 之后的又一热门免疫检查点，LAG-3 能通过多种途径调节免疫系统功能，如LAG-3 可调节T 细胞的耗竭、活化和肿瘤识别杀伤能力，调节Treg 细胞的免疫等。该文综述LAG-3 在免疫细胞调节中的功能和机制，及其参与抗肿瘤治疗及药物研发的进展，为LAG-3 作为靶点的临床应用和药物研发提供启示。

通讯作者：刘　松 , Email:songliu@gdpu.edu.cn

Research progress of immune checkpoint LAG-3 in anti-tumor immunotherapy

CHEN Jin-Hui¹ , LIU Shi-Wen¹ , HE Qing-Xi¹ , LAI Guan-Xi² , SHAO Hong-Wei¹ , LIU Song^1,2,3,*

¹Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Guangdong Pharmaceutical University, Guangzhou 510006, China ²School of Pharmacy & Clinical Pharmacy (School of Integrative Pharmacy), Guangdong Pharmaceutical University, Guangzhou 510006, China ³Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China

Abstract:

After programmed death receptor-1 (PD-1) and cytotoxic T lymphocyte associated protein 4 (CTLA-4), the lymphocyte activation gene-3 (LAG-3) is becoming a more and more popular immune checkpoint. LAG-3 regulates immune system through different signaling pathways. For example, LAG-3 regulates the exhaust, activation, and tumor recognition and killing ability of T cells, as well as the cellular immunity of Treg cells. Here, the function and mechanism of LAG-3 in regulating immune cells, its progress on antitumor immunotherapy and drug development were reviewed, which may provide reference for the LAG-3 based clinical application and drug development.

Communication Author：LIU Song , Email:songliu@gdpu.edu.cn