《生命科学》 2023, 35(11): 1517-1526

长非编码RNA作为ceRNA分子在乳腺癌中的调控机制

鲍　宇 , 张素花^*

河北工业大学生物物理研究所，天津 300400

摘　要：

乳腺癌是全球女性最常见的异质性恶性肿瘤，分为多种亚型，不同亚型的临床治疗方式和效果不同。多项研究表明长非编码RNA(lncRNA) 在乳腺癌的进展中起着关键作用，其中由lncRNA-miRNA-mRNA 相互作用形成的ceRNA 网络是RNA 分子间的一种新调节机制。LncRNA 通过该网络广泛参与乳腺癌的增殖、迁移、凋亡等多种生物学过程，可作为诊断和治疗的分子靶点。该文重点阐述了lncRNA 介导的ceRNA 调控机制，系统总结了lncRNA 相关ceRNA 网络在调控不同乳腺癌亚型的增殖、迁移和耐药性中的研究进展，旨在为乳腺癌的精准治疗和lncRNA 研究提供新见解。

通讯作者：张素花 , Email:zhangsuhua76@163.com

Regulation mechanism of long non-coding RNA as a ceRNA molecule in breast cancer

BAO Yu , ZHANG Su-Hua^*

Institute of Biophysics, Hebei University of Technology, Tianjin 300400, China

Abstract:

Breast cancer is the most common heterogeneous malignant tumor among women worldwide. It can be divided into many subtypes and different subtypes have different clinical  treatment methods and effects. Multiple studies have shown that long non- coding RNA (lncRNA) plays a crucial role in the progression of breast cancer. The ceRNA networks based on lncRNA-miRNA-mRNA interactions have   revealed a new regulatory mechanism between RNA molecules. LncRNAs are widely involved in the proliferation,  migration, apoptosis and other biological processes of breast cancer through ceRNA network, and can be  used as molecular targets for diagnosis and treatment. This review focuses on  the lncRNA-mediated ceRNA regulation mechanism, and systematically summarizes the research progress of lncRNA-mediated ceRNA networks in  regulating the proliferation, migration and drug resistance of different breast cancer subtypes, in order to provide  new insights for the precise treatment of breast cancer and lncRNA research.

Communication Author：ZHANG Su-Hua , Email:zhangsuhua76@163.com