《生命科学》 2023, 35(11): 1450-1461

肿瘤免疫中TCR的有效多样性研究

张小敏¹ , 赵海洋¹ , 李杰威² , 刘晓艳¹ , 侯大斌¹ , 张翼冠³ , 魏　平^3,*

¹西南科技大学生命科学与工程学院，绵阳 621010 ²四川师范大学计算机科学学院，成都610101 ³四川省中医药科学院/四川省中医药转化医学中心/中医药转化医学四川省重点实验室，成都 610041

摘　要：

T 细胞是抗癌免疫系统的主要组成部分，其表面表达的特定T 细胞受体(T cell receptor, TCR) 负责识别抗原肽并引发免疫反应。在肿瘤免疫研究中，分析TCR 的多样性和特异性对于理解适应性免疫应答和免疫治疗至关重要。目前的研究侧重于单独分析多样性或特异性，尽管这两者都与肿瘤的有效免疫相关，但并非总是呈现正相关。本文探讨了肿瘤免疫中TCR 的多样性和特异性研究进展及面临的挑战，指出综合分析多样性和特异性的必要性，给出综合性概念——TCR 有效多样性的定义，介绍并讨论了已有的少量相关研究成果。揭示有效多样性的科学意义需要综合分析TCR 的多样性、特异性和有效性，结合充分的实验来进行建模和量化表征。有效多样性对于深入了解TCR 在肿瘤中的作用至关重要，对于未来的癌症早筛、治疗和预后具有潜在的重要意义。

通讯作者：魏　平 , Email:w.ping@foxmail.com

Effective diversity research of TCR in tumor immunity

ZHANG Xiao-Min¹ , ZHAO Hai-Yang¹ , LI Jie-Wei² , LIU Xiao-Yan¹ , HOU Da-Bin¹ , ZHANG Yi-Guan³ , WEI Ping^3,*

¹School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China ²College of Computer Science, Sichuan Normal University, Chengdu 610101, China ³Sichuan Academy of Traditional Chinese Medicine/Sichuan Center of Translational Medicine/Sichuan Key Laboratory of Translational Medicine of Traditional Chinese Medicine, Chengdu 610041, China

Abstract:

T cells are a major component of the anti-cancer immune system, and their surface-expressed specific T cell receptors (TCRs) are responsible for recognizing antigen peptides and initiating immune responses. In the field of tumor immunology, understanding the diversity and specificity of TCRs is crucial for comprehending adaptive immune responses and immunotherapy. Current research primarily focuses on analyzing diversity or specificity separately, and although both are associated with effective immunity to tumors, they do not always show a positive correlation. This article discusses the research progress and challenges of TCR diversity and specificity in tumor immunity, points out the necessity of comprehensive analysis of diversity and specificity, gives the definition of comprehensive concept “TCR effective diversity”, and introduces and analyzes a few relevant research results. Revealing the scientific significance of effective diversity requires a comprehensive analysis of the diversity, specificity, and effectiveness of TCRs, combined with adequate experiments for modeling and quantitative characterization. Effective diversity is essential for in-depth understanding of the role of TCR in tumors and has potentially important implications for early screening, treatment and prognosis of cancer in the future.

Communication Author：WEI Ping , Email:w.ping@foxmail.com