《生命科学》 2023, 35(10): 1380-1387

巨噬细胞外泌体在增殖性糖尿病视网膜病变中的研究进展

汪梦竹¹ , 蔡　畅¹ , 刘　洋¹ , 宋洪元² , 沈　炜^2,*

¹海军军医大学基础医学院学员一大队，上海 200433 ²海军军医大学长海医院眼科，上海 200433

摘　要：

糖尿病视网膜病变(diabetic retinopathy, DR) 是糖尿病患者最常见的微血管系统并发症之一，是视力丧失的主要原因。增殖性糖尿病视网膜病变(proliferative diabetic retinopathy, PDR) 是DR 的终末期表现，其主要的病理生理学特征是视网膜新生血管形成(retinal neovascularization, RNV)。但PDR 现有治疗方式存在局限性。外泌体作为细胞间沟通交流的重要使者，其携带的非编码RNA 和生物活性蛋白质等重要信号分子，通过影响血管内皮细胞的增殖和迁移，在RNV 中发挥关键作用。巨噬细胞是一种多功能调节细胞，越来越多的研究表明巨噬细胞外泌体在调控新生血管形成中起重要作用。该文就巨噬细胞外泌体在增殖性糖尿病视网膜病变形成中的作用与机制研究进展进行综述。

通讯作者：沈　炜 , Email:shenwzz@163.com

Research progress of macrophage-derived exosomes in proliferative diabetic retinopathy

WANG Meng-Zhu¹ , CAI Chang¹ , LIU Yang¹ , SONG Hong-Yuan² , SHEN Wei^2,*

¹Brigade One Team, Basic Medical College, Naval Medical University, Shanghai 200433, China ²Department of Ophthalmology, Changhai Hospital, Naval Medical University, Shanghai 200433, China

Abstract:

Diabetic retinopathy (DR) is one of the most common microvascular system complications in diabetic patients, and is the main cause of vision loss. Proliferative diabetic retinopathy (PDR) is the end-stage manifestation of DR, while its main pathophysiological feature is retinal neovascularization (RNV). However, existing treatments for PDR have limitations. As an important messenger between cells, exosomes carry important signaling molecules such as non-coding RNA and bioactive proteins, which play a key role in RNV by affecting the proliferation and migration of vascular endothelial cells. Macrophages are multifunctional regulatory cells, and more and more studies have shown that macrophage-derived exosomes play an important role in regulating neovascularization. This article reviews the research progress on the role and mechanism of macrophage-derived exosomes in the formation of proliferative diabetic retinopathy.

Communication Author：SHEN Wei , Email:shenwzz@163.com