《生命科学》 2023, 35(10): 1372-1379

尿酸与DNA损伤之间关系的研究进展

曾　佳¹ , 白　雪^2,3 , 尹相林^1,3 , 赵泊宇¹ , 关宝^1,3,*

¹佳木斯大学公共卫生学院，佳木斯 154007 ²佳木斯大学基础医学院， 佳木斯 154007 ³黑龙江省痛风研究重点实验室，佳木斯 154007

摘　要：

尿酸是人体嘌呤代谢的最终产物，高于生理浓度的尿酸通常伴随细胞内氧化应激和活性氧(reactive oxygen species, ROS) 增多，进而造成细胞内DNA 损伤。DNA 损伤反应及其引起的细胞死亡会促进内源性嘌呤增多，进一步导致尿酸升高。同时，DNA 损伤反应可引起炎症、胰岛素抵抗、脂质代谢等异常，从而导致糖尿病、慢性肾脏疾病、非酒精性脂肪肝病等疾病的发生。这可能是高浓度尿酸成为多种慢性代谢性疾病独立危险因素的原因之一。因此，研究尿酸与DNA 损伤之间的关系有助于深入了解尿酸的生理功能，为预防高尿酸血症及其相关疾病，并寻找潜在治疗靶点提供理论依据。

通讯作者：关宝 , Email:gbs@jmsu.edu.cn

Research progress on the relationship between uric acid and DNA damag

ZENG Jia¹ , BAI Xue^2,3 , YIN Xiang-Lin^1,3 , ZHAO Bo-Yu¹ , GUAN Bao-Sheng^1,3,*

¹School of Public Health, Jiamusi University, Jiamusi 154007, China ²School of Basic Medicine, Jiamusi University, Jiamusi 154007, China ³Heilongjiang Provincial Key Laboratory of Gout Research, Jiamusi 154007, China

Abstract:

Uric acid is the end product of purine metabolism in human body. High uric acid are usually accompanied by an increase in intracellular oxidative stress and reactive oxygen species (ROS), inducing intracellular DNA damage. DNA damage response (DDR) and cell death induced by DDR will increase endogenous purines, which will further contribute to the elevation of uric acid. In addition, DDR can cause inflammation, insulin resistance, lipid metabolism and other abnormalities, leading to diseases such as diabetes, chronic kidney disease, and nonalcoholic fatty liver disease. This may be one of the reasons why high uric acid can act as an independent risk factor for several chronic metabolic diseases. Therefore, researching the relationship between uric acid and DNA damage is conducive to a deeper understanding of the physiological function of uric acid and provides a theoretical basis for finding potential targets to prevent and treat hyperuricemia and related diseases.

Communication Author：GUAN Bao-Sheng , Email:gbs@jmsu.edu.cn