《生命科学》 2023, 35(10): 1348-1357

非酒精性脂肪性肝病诊断方法研究进展

孙福广^1,2 , 任　进^1,2,*

¹中国科学院上海药物研究所，上海 201203 ²中国科学院大学，北京 100049

摘　要：

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD) 是一类进行性的慢性肝脏疾病，包括简单的脂肪蓄积、非酒精性脂肪性肝炎、进展性的肝纤维化、肝硬化和肝细胞肝癌。NAFLD 具有致病机制复杂、疾病进行性、高发病率、伴随并发症风险以及无特效药物治疗等特征，这凸显出对NAFLD 的发病机制认知、筛查、诊断与监测的重要性。因此，该文旨在介绍NAFLD 的概况，着重从肝穿刺组织活检、影像学检查和血液标志物三个方面归纳与总结诊断方法的研究进展，为NAFLD 的基础研究、临床诊断及其新的生物标志物研究提供相关的参考。

通讯作者：任　进 , Email:jren@cdser.simm.ac.cn

Advances in the diagnosis of nonalcoholic fatty liver disease

SUN Fu-Guang^1,2 , REN Jin^1,2,*

¹Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China ²University of Chinese Academy of Sciences, Beijing 100049, China

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a type of progressive chronic liver diseases that encompasses non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD is characterized by complicated pathogenesis, progressivity, high incidence, risk of complications and no specific drugs, which highlights the importance of NAFLD pathogenesis understanding, screening, diagnosis and monitoring. Therefore, we aim to review NAFLD and emphatically summarize its diagnostic techniques including liver biopsy, imaging and blood biomarkers, in order to provide reference for the research and clinical diagnosis of NAFLD.

Communication Author：REN Jin , Email:jren@cdser.simm.ac.cn