《生命科学》 2023, 35(10): 1337-1347
通讯作者：曹中赞 , Email:email@example.com 栾新红 , Email:firstname.lastname@example.org
Adiponectin is an important endogenous bioactive hormone in human and animals, which has the functions of improving insulin resistance, regulating lipid metabolism, anti-atherosclerosis, protecting the heart, antiinflammation, anti-oxidative stress, anti-fibrosis and regulating apoptosis. Adiponectin needs to bind to its receptor to exert its biological function, but its clinical application is limited to some extent due to its structure and concentration. It has been found that many adiponectin receptor agonists play similar biological functions to adiponectin by activating adiponectin receptor, and adiponectin receptor agonists are mostly synthetic small molecules or screened polypeptides, with more clear effect. This review summarizes the adiponectin receptor agonists and their reported research progress, and outlines their effects on liver, kidney, heart, blood vessel, eye, skin and other related organs or tissue diseases, whereby provides a theoretical basis for the development of therapeutic drugs based on adiponectin and its receptors.
Communication Author：CAO Zhong-Zan , Email:email@example.com LUAN Xin-Hong , Email:firstname.lastname@example.org