《生命科学》 2023, 35(10): 1322-1327
通讯作者：郭 军 , Email:firstname.lastname@example.org
The vital activity of human cells depends on membrane potential polarization and the asymmetric dynamic balance of intracellular and extracellular ions (also known as bio-osmotic pressure balance). Changes in membrane potential and ion composition have effects in how cells respond to physical and chemical stimuli, regulating their adaptation to environmental changes. Recent studies have shown that protein nanoparticle alterations in human plasma and cells are crucial in the regulation of cellular membrane potential, which is closely related to the intra/extracellular ions redistribution and transmembrane osmotic pressure changes. The activation and degree of opening of voltage-dependent ion channels are important regulatory mechanisms for inducing ions redistribution. Their activity is closely related to the alteration of membrane potential regulated by protein nanoparticles. In addition, the ion composition influences the changes of membrane potential induced by protein nanoparticle adsorbing ions. Thus, protein nanoparticles are important physical mechanisms for regulating cellular membrane potential and osmotic pressure balance. This synergistic regulation of electromechanical activity has a direct impact on the occurrence and treatment of various diseases associated with protein nanoparticles. The discovery of this mechanism may open up a new avenue of investigation into the pathophysiology of challenging clinical disorders.
Communication Author：GUO Jun , Email:email@example.com