《生命科学》 2023, 35(10): 1267-1278

基于氧化应激探讨热量限制及其模拟物改善心血管疾病的研究进展

张　慧 , 李婷婷 , 张铭宸 , 张萍萍 , 王孝文^* , 孙忠广^*

潍坊医学院康复医学院，潍坊 261053

摘　要：

氧化应激能够导致心血管系统氧化与抗氧化的失衡，引起细胞化学损害，从而导致疾病的发生和发展。热量限制(caloric restriction, CR) 通过改善机体氧化应激状态，可以降低心血管疾病风险。本文介绍了氧化应激与心血管疾病的关系，概括了CR 对氧化应激的各方面调控机制，并探讨了几种常见热量限制模拟物(caloric restriction mimetics, CRM) 调节氧化应激水平的主要通路，以期深入了解心血管疾病的发病机制，探求更科学有效的药物靶点。

通讯作者：王孝文 , Email:wangxiaowen2003@163.com 孙忠广 , Email:sunzhongguang@outlook.com

Research progress on roles of caloric restriction and its mimics in improving cardiovascular diseases based on oxidative stress

ZHANG Hui , LI Ting-Ting , ZHANG Ming-Chen , ZHANG Ping-Ping , WANG Xiao-Wen^* , SUN Zhong-Guang^*

School of Rehabilitation Medical, Weifang Medical University, Weifang 261053, China

Abstract:

Oxidative stress can induce imbalance between oxidation and antioxidants in the cardiovascular system and then cause chemical damage to cells, playing a role in the occurrence and development of diseases. Caloric restriction (CR) can reduce the risk of cardiovascular diseases by improving the body’s oxidative stress state. This article briefly discusses the relationship between oxidative stress and cardiovascular diseases, and reviews the regulation mechanism of CR on oxidative stress in various aspects. In addition, this article also introduces several common caloric restriction mimics and explains the main pathways through which they regulate the level of oxidative stress. In this way, we can gain an in-depth understanding of the pathogenesis of cardiovascular diseases, and explore more scientific and effective drug targets.

Communication Author：WANG Xiao-Wen , Email:wangxiaowen2003@163.com SUN Zhong-Guang , Email:sunzhongguang@outlook.com