《生命科学》 2023, 35(9): 1223-1234

运动改善青春期间歇性酒精暴露诱导认知损伤的神经炎症机制

郭燕霞¹ , 李　丽¹ , 李　岩^1,2,*

¹北京体育大学运动生理学教研室，北京 100084 ²北京体育大学运动与体质健康教育部重点实验室，北京 100084

摘　要：

青春期间歇性酒精暴露诱导的认知损伤可以持续至成年，运动作为一种非药物治疗手段可以有效治疗青春期间歇性酒精暴露，但其神经炎症机制远未明了。本文旨在探究内源性大麻素系统通过调控小胶质细胞及其介导的神经炎症，在运动改善青春期间歇性酒精暴露诱导认知障碍中的重要作用。

通讯作者：李　岩 , Email:bsuliyan@bsu.edu.cn

The neuroinflammation machanisms of exercise relieving adolescent intermittent ethanol exposure-induced cognitive impairment

GUO Yan-Xia¹ , LI Li¹ , LI Yan^1,2,*

¹Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China ²Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China

Abstract:

Adolescent intermittent ethanol exposure-induced cognitive impairment will persist into adulthood. Exercise has been shown benefit as a non-pharmacological method for treating adolescent intermittent ethanol exposure. However, the neuroinflammation mechanisms underlying the beneficial effects remain unclear. The present study is to explore the significant role of endocannabinoid system in exercise-mediated adolescent intermittent ethanol exposure-induced cognitive impairment by suppressing microglia-mediated neuroinflammation.

Communication Author：LI Yan , Email:bsuliyan@bsu.edu.cn