《生命科学》 2023, 35(9): 1200-1206

AIM2炎症小体介导细胞焦亡的研究进展

陈　英 , 朱静静 , 左　琦 , 杨　艳 , 翟　亮 , 李京旻 , 万千慧 , 邵思亿 , 姜婷婷 , 吴曙辉^*

上海中医药大学附属宝山医院，上海 201999

摘　要：

细胞焦亡是一种程序性细胞死亡，参与了多种疾病的发生发展，而炎症反应在细胞焦亡中的作用是目前的研究热点。炎症小体是炎症反应的重要组成部分，其中黑色素瘤缺乏因子 2 (absent in melanoma 2, AIM2) 炎症小体的激活是诱发由含半胱氨酸的天冬氨酸蛋白酶1 (caspase-1) 介导的细胞焦亡的重要因素。靶向AIM2 炎症小体激活与细胞焦亡可作为临床相关疾病治疗的有效策略，本文综述了AIM2 炎症小体介导的细胞焦亡的研究进展。

通讯作者：吴曙辉 , Email:wsh-1227@163.com

Research progress on AIM2 inflammasome-mediated pyroptosis

CHEN Ying , ZHU Jing-Jing , ZUO Qi , YANG Yan , ZHAI Liang , LI Jing-Min , WAN Qian-Hui , SHAO Si-Yi , JIANG Ting-Ting , WU Shu-Hui^*

Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China

Abstract:

Pyroptosis is a kind of programmed cell death that is involved in the initial and progressive process of various diseases, and the role of inflammatory response in pyroptosis is the focus of current research. Inflammasome is an important component of the inflammatory response, in which the activation of AIM2 inflammasome is an important factor in inducing pyroptosis mediated by cysteine-containing aspartate  protease 1 (caspase-1). Targeting AIM2 inflammasome activation and  pyroptosis can be an effective strategy for the treatment of clinically relevant diseases. In this review, we mainly focus on the recent advances on pyroptosis  mediated by AIM2 inflammasome.

Communication Author：WU Shu-Hui , Email:wsh-1227@163.com