《生命科学》 2023, 35(9): 1192-1199

胞内DNA感受器及其在癌症中的研究进展

葛刘欣 , 周佳敏 , 林　玮 , 李科志 , 周素芳^*

广西医科大学基础医学院生物化学与分子生物学教研室，长寿与老年相关疾病教育部重点实验室，广西 高校生物分子医学研究重点实验室，区域性高发肿瘤早期防治研究教育部重点实验室，南宁 530021

摘　要：

胞内DNA 感受器是DNA 片段的模式识别受体(pattern recognition receptor, PRR)，通过激活细胞内部的不同信号通路参与调控先天免疫防御和细胞程序性死亡，不同感受器之间存在调节作用，共同维持机体的稳态。随着研究的深入，发现胞内DNA 感受器的表达在肿瘤的发生发展中发挥重要作用，其参与肿瘤免疫调节的功能有望作为抗癌新靶点，为临床肿瘤治疗提供更多新方向。本综述旨在介绍胞内DNA感受器的激活机制和肿瘤调节机制，及其在临床抗癌研究和应用中的最新进展。

通讯作者：周素芳 , Email:zsf200000@163.com

Research progress of intracellular DNA sensor and its application in cancer

GE Liu-Xin , ZHOU Jia-Min , LIN Wei , LI Ke-Zhi , ZHOU Su-Fang^*

Key Laboratory of Early Prevention and Treatment of Regional High-Frequency Tumors of the Ministry of Education, Key Laboratory of Biomolecular Medicine Research in Guangxi Universities, Key Laboratory of Longevity and Agingrelated Diseases of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China

Abstract:

Intracellular DNA biosensor is the pattern recognition receptor (PRR) of DNA fragment, which participates in the regulation of innate immune defense and programmed cell death by activating different signal pathways. With the deepening of research, the expression of intracellular DNA sensor has been demonstrated to play an important role in the occurrence and development of tumor. Its function of participating in tumor immune regulation is expected to be a new target of anticancer and provide more new directions for clinical tumor therapy. This review introduces the activation mechanism and tumor regulation mechanism of intracellular DNA sensor, as well as the latest progress in clinical anticancer research and application.

Communication Author：ZHOU Su-Fang , Email:zsf200000@163.com