《生命科学》 2023, 35(9): 1177-1184

组蛋白甲基化介导血管平滑肌细胞功能失调在血管疾病中的研究进展

杨子姝^1,2,3 , 张　静^1,2,3 , 黄萃园^2,3 , 刘　丽^2,3 , 杨　简^1,2,3,*

¹三峡大学第一临床医学院&宜昌市中心人民医院，心血管内科，宜昌 443003 ²三峡大学心血管 病研究所，宜昌 443002 ³湖北省缺血性心血管疾病临床医学研究中心，宜昌 443003

摘　要：

血管平滑肌细胞(vascular smooth muscle cells, VSMC) 是动脉血管的主要细胞组分之一，其正常形态功能对维持动脉血管发育、舒缩及损伤修复具有重要意义。反之，VSMC 在病理状态下的异常活化、表型转换或过度死亡亦会导致动脉结构受损。近来研究发现，组蛋白甲基化修饰在VSMC 自噬、增殖迁移与表型分化等过程中发挥了关键的调控作用。本文综述了组蛋白甲基化在VSMC 功能障碍中的调节作用，包括增殖、分化、迁移和自噬等方面；同时，探讨了不同组蛋白甲基化转移酶及去甲基化转移酶对VSMC 功能的影响。由于VSMC 功能障碍会导致血管疾病的发生和发展，因此表观遗传学修饰的可逆性为基于组蛋白甲基化的干预方案提供了理论依据。本文进一步探讨了组蛋白甲基化介导的VSMC 功能障碍与相关血管疾病之间的联系，以期为深入研究组蛋白甲基化在血管疾病中的关键作用提供依据。

通讯作者：杨　简 , Email:yangjian@ctgu.edu.cn

Research progress on dysfunction of smooth muscle cells mediated by histone methylation in vascular diseases

YANG Zi-Shu^1,2,3 , ZHANG Jing^1,2,3 , HUANG Cui-Yuan^2,3 , LIU Li^2,3 , YANG Jian^1,2,3,*

¹Department of Cardiovascular Medicine, The First Clinical Medical College of China Three Gorges University & Yichang Central People's Hospital, Yichang 443003, China ²Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443002, China ³Hubei Clinical Medical Research Center for Ischemic Cardiovascular Diseases, Yichang 443003, China

Abstract:

Vascular smooth muscle cells (VSMC) are essential components of arteries, responsible for maintaining normal arterial development, contraction, and repair. However, under pathological conditions, abnormal activation, phenotype conversion, or excessive cell death of VSMC can lead to arterial damage. Recent researches have unveiled the significant regulatory role of histone methylation in key processes such as autophagy, proliferation, migration, and phenotypic differentiation of VSMC. This review explores the impact of histone methylation on the dysfunction of VSMC, specifically focusing on proliferation, differentiation, migration, and autophagy. Additionally, the effects of different histone methyltransferases and demethyltransferases on VSMC are discussed. Considering that VSMC dysfunction contributes to the development and progression of  vascular diseases, the reversibility of epigenetic modifications offers potential for intervention strategies targeting histone methylation. The connections between histone methylation-mediated VSMC dysfunction and vascular diseases are also investigated, aiming to provide conference for exploring the critical role of histone methylation in the  pathogenesis of vascular diseases.

Communication Author：YANG Jian , Email:yangjian@ctgu.edu.cn